One-pot synthesis of 2-pyridones via chemo- and regioselective tandem Blaise reaction of nitriles with propiolates

Sung Chun Yu, Yeon Ryu Ka, Ok Ko Young, Yeon Hong Joo, Jongki Hong, Hyunik Shin, Sang Gi Lee

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

(Chemical Equation Presented) The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with propiolates in a chemo- and regioselective manner to afford 2-pyridone derivatives in good to excellent yields.

Original languageEnglish
Pages (from-to)7556-7558
Number of pages3
JournalJournal of Organic Chemistry
Volume74
Issue number19
DOIs
StatePublished - 2 Oct 2009

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