One-pot synthesis of 2-pyridones via chemo- and regioselective tandem Blaise reaction of nitriles with propiolates

Sung Chun Yu; Yeon Ryu Ka; Ok Ko Young; Yeon Hong Joo; Jongki Hong; Hyunik Shin; Sang Gi Lee

doi:10.1021/jo901642t

One-pot synthesis of 2-pyridones via chemo- and regioselective tandem Blaise reaction of nitriles with propiolates

Sung Chun Yu, Yeon Ryu Ka, Ok Ko Young, Yeon Hong Joo, Jongki Hong, Hyunik Shin, Sang Gi Lee

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

(Chemical Equation Presented) The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with propiolates in a chemo- and regioselective manner to afford 2-pyridone derivatives in good to excellent yields.

Original language	English
Pages (from-to)	7556-7558
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	74
Issue number	19
DOIs	https://doi.org/10.1021/jo901642t
State	Published - 2 Oct 2009

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title = "One-pot synthesis of 2-pyridones via chemo- and regioselective tandem Blaise reaction of nitriles with propiolates",

abstract = "(Chemical Equation Presented) The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with propiolates in a chemo- and regioselective manner to afford 2-pyridone derivatives in good to excellent yields.",

author = "Yu, {Sung Chun} and Ka, {Yeon Ryu} and Young, {Ok Ko} and Joo, {Yeon Hong} and Jongki Hong and Hyunik Shin and Lee, {Sang Gi}",

year = "2009",

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T1 - One-pot synthesis of 2-pyridones via chemo- and regioselective tandem Blaise reaction of nitriles with propiolates

AU - Yu, Sung Chun

AU - Ka, Yeon Ryu

AU - Young, Ok Ko

AU - Joo, Yeon Hong

AU - Hong, Jongki

AU - Shin, Hyunik

AU - Lee, Sang Gi

PY - 2009/10/2

Y1 - 2009/10/2

N2 - (Chemical Equation Presented) The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with propiolates in a chemo- and regioselective manner to afford 2-pyridone derivatives in good to excellent yields.

AB - (Chemical Equation Presented) The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with propiolates in a chemo- and regioselective manner to afford 2-pyridone derivatives in good to excellent yields.

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U2 - 10.1021/jo901642t

DO - 10.1021/jo901642t

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VL - 74

SP - 7556

EP - 7558

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 19

ER -

One-pot synthesis of 2-pyridones via chemo- and regioselective tandem Blaise reaction of nitriles with propiolates

Abstract

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