Oligopeptide delivery carrier for osteoclast precursors

Bo Chi, So Jeong Park, Min Hee Park, Soo Young Lee, Byeongmoon Jeong

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Dendritic amine and guanidinium group-modified nanoparticles were investigated for the delivery of model peptide drug into primary osteoclast precursor cells (bone marrow macrophages; BMMs). The model peptide drug was encapsulated into the nanoparticle by dropping the drug/carrier dissolved in dimethylsulfoxide/methylene chloride cosolvent into water containing poly(vinyl alcohol) as a stabilizer. Flow cytometry and spectrofluorimetry analysis indicated that the model drug itself was not taken up by the BMMs; however, nanoparticle systems underwent significant cellular uptake. In particular, guanidinium group-modified nanoparticles were taken up more efficiently than amine group-modified ones. Cell viability studies showed that both amine and guanidinium group-modified nanoparticles exhibited no significant cytotoxicity up to 100 μg/mL against the cells.

Original languageEnglish
Pages (from-to)1473-1478
Number of pages6
JournalBioconjugate Chemistry
Issue number8
StatePublished - 18 Aug 2010


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