Abstract
Purpose: To evaluate changes in ocular surface indices and tear cytokines after cataract surgery in type 2 diabetic patients. Methods: Ocular surface indices and concentrations of tear cytokines (MCP-1, IL-6, IL-8, and VEGF) were evaluated at baseline and one week and one month postoperatively. Results: Patients (30 diabetic and 30 control) were enrolled. In the diabetic group, changes in ocular symptom and tear breakup time remained until one month postoperatively (P < .05, respectively); in the control group, ocular symptom increased at one week postoperatively (P = .015). MCP-1 level in the diabetic group significantly increased postoperatively (all P < .05); however, in the control group, the IL-8 level was significantly decreased postoperatively (all P < .05). MCP-1 concentration was negatively correlated with TBUT in the diabetic group. Conclusion: Diabetic patients can experience more prominent changes after surgery and these changes were accompanied by an increase of several tear cytokines.
| Original language | English |
|---|---|
| Pages (from-to) | 1615-1622 |
| Number of pages | 8 |
| Journal | Ocular Immunology and Inflammation |
| Volume | 31 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2023 |
Bibliographical note
Publisher Copyright:© 2022 Taylor & Francis Group, LLC.
Keywords
- Cataract surgery
- cytokines
- ocular surface parameters
- tear
- type 2 diabetes mellitus
