Abstract
Computed tomographic (CT) is a fundamental imaging modality to generate cross-sectional views of internal anatomy in a living subject or interrogate material composition of an object, and it has been routinely used in clinical applications and nondestructive testing. In a standard CT image, pixels having the same Houns-eld Units (HU) can correspond to different materials, and it is therefore challenging to differentiate and quantify materials. Dual-energy CT (DECT) is desirable to differentiate multiple materials, but the costly DECT scanners are not widely available as single-energy CT (SECT) scanners. Recent advancement in deep learning provides an enabling tool to map images between different modalities with incorporated prior knowledge. Here we develop a deep learning approach to perform DECT imaging by using the standard SECT data. The end point of the approach is a model capable of providing the high-energy CT image for a given input low-energy CT image. The feasibility of the deep learning-based DECT imaging method using a SECT data is demonstrated using contrast-enhanced DECT images and evaluated using clinical relevant indexes. This work opens new opportunities for numerous DECT clinical applications with a standard SECT data and may enable significantly simplified hardware design, scanning dose and image cost reduction for future DECT systems.
Original language | English |
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Pages (from-to) | 139-148 |
Number of pages | 10 |
Journal | Pacific Symposium on Biocomputing |
Volume | 25 |
Issue number | 2020 |
State | Published - 2020 |
Event | 25th Pacific Symposium on Biocomputing, PSB 2020 - Big Island, United States Duration: 3 Jan 2020 → 7 Jan 2020 |
Bibliographical note
Publisher Copyright:© 2019 The Authors.
Keywords
- Convolutional neural network
- Deep learning
- Dual-energy computed tomography
- Io-dine quantification.
- Material decomposition
- Single-energy computed tomography
- Virtual non-contrast