Observing hydrogen sulfide in the endoplasmic reticulum of cancer cells and zebrafish by using an activity-based fluorescent probe

Yves S. Kafuti; Shuang Zeng; Xiaosheng Liu; Jingjing Han; Ming Qian; Qixian Chen; Jingyun Wang; Xiaojun Peng; Juyoung Yoon; Haidong Li

doi:10.1039/d2cc06645a

Observing hydrogen sulfide in the endoplasmic reticulum of cancer cells and zebrafish by using an activity-based fluorescent probe

Yves S. Kafuti, Shuang Zeng, Xiaosheng Liu, Jingjing Han, Ming Qian, Qixian Chen, Jingyun Wang, Xiaojun Peng, Juyoung Yoon, Haidong Li

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A crucial endogenous signaling chemical, hydrogen sulfide, is involved in many physiological actions. In this work, we created the fluorescent probe ER-Nap-NBD using a naphthalimide fluorophore as the signal reporter, a 7-nitro-1,2,3-benzoxadiazole amine as the responsive moiety, and a sulfonamide part for endoplasmic reticulum targeting. ER-Nap-NBD could be detected the H₂S levels in solution and in living systems (cells and zebrafish).

Original language	English
Pages (from-to)	2493-2496
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	17
DOIs	https://doi.org/10.1039/d2cc06645a
State	Published - 4 Feb 2023

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© 2023 The Royal Society of Chemistry.

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abstract = "A crucial endogenous signaling chemical, hydrogen sulfide, is involved in many physiological actions. In this work, we created the fluorescent probe ER-Nap-NBD using a naphthalimide fluorophore as the signal reporter, a 7-nitro-1,2,3-benzoxadiazole amine as the responsive moiety, and a sulfonamide part for endoplasmic reticulum targeting. ER-Nap-NBD could be detected the H2S levels in solution and in living systems (cells and zebrafish).",

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AU - Kafuti, Yves S.

AU - Zeng, Shuang

AU - Liu, Xiaosheng

AU - Han, Jingjing

AU - Qian, Ming

AU - Chen, Qixian

AU - Wang, Jingyun

AU - Peng, Xiaojun

AU - Yoon, Juyoung

AU - Li, Haidong

PY - 2023/2/4

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AB - A crucial endogenous signaling chemical, hydrogen sulfide, is involved in many physiological actions. In this work, we created the fluorescent probe ER-Nap-NBD using a naphthalimide fluorophore as the signal reporter, a 7-nitro-1,2,3-benzoxadiazole amine as the responsive moiety, and a sulfonamide part for endoplasmic reticulum targeting. ER-Nap-NBD could be detected the H2S levels in solution and in living systems (cells and zebrafish).

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Observing hydrogen sulfide in the endoplasmic reticulum of cancer cells and zebrafish by using an activity-based fluorescent probe

Abstract

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