Observing hydrogen sulfide in the endoplasmic reticulum of cancer cells and zebrafish by using an activity-based fluorescent probe

Yves S. Kafuti, Shuang Zeng, Xiaosheng Liu, Jingjing Han, Ming Qian, Qixian Chen, Jingyun Wang, Xiaojun Peng, Juyoung Yoon, Haidong Li

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

A crucial endogenous signaling chemical, hydrogen sulfide, is involved in many physiological actions. In this work, we created the fluorescent probe ER-Nap-NBD using a naphthalimide fluorophore as the signal reporter, a 7-nitro-1,2,3-benzoxadiazole amine as the responsive moiety, and a sulfonamide part for endoplasmic reticulum targeting. ER-Nap-NBD could be detected the H2S levels in solution and in living systems (cells and zebrafish).

Original languageEnglish
Pages (from-to)2493-2496
Number of pages4
JournalChemical Communications
Volume59
Issue number17
DOIs
StatePublished - 4 Feb 2023

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© 2023 The Royal Society of Chemistry.

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