Novel platinum complexes having chirality and free tertiary amine groups for multiple interactions with DNA

Mi Sook Seo; Youn Soo Sohn; Beom Seok Yang; Wonwoo Nam; Kwan Mook Kim

doi:10.1016/j.inoche.2004.09.007

Novel platinum complexes having chirality and free tertiary amine groups for multiple interactions with DNA

Mi Sook Seo, Youn Soo Sohn, Beom Seok Yang, Wonwoo Nam, Kwan Mook Kim

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Chiral ethylenediamine ligands with free tertiary amine groups and their platinum complexes are synthesized. The platinum complexes have both chirality and additional DNA interacting groups. The hydrogen bonding interactions in the crystal structure lead to the dimerization of two platinum complexes having pocket-like cavity with chiral shapes. Chiral ethylenediamine ligands with free tertiary amine groups and their platinum complexes are synthesized. The platinum complexes have both chirality and additional DNA interacting groups. The hydrogen bonding interactions between chlorides and two tertiary amine groups in the crystal structure lead to the dimerization of two platinum complexes having pocket-like cavity with chiral shapes.

Original language	English
Pages (from-to)	1178-1180
Number of pages	3
Journal	Inorganic Chemistry Communications
Volume	7
Issue number	11
DOIs	https://doi.org/10.1016/j.inoche.2004.09.007
State	Published - Nov 2004

Bibliographical note

Funding Information:
This work was supported by a grant from MOST through the Creative Research Initiative Program and Ewha Womans University (2004-033-1).

Keywords

Anticancer
Chiral amine
Multiple DNA interaction
Platinum

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10.1016/j.inoche.2004.09.007

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title = "Novel platinum complexes having chirality and free tertiary amine groups for multiple interactions with DNA",

abstract = "Chiral ethylenediamine ligands with free tertiary amine groups and their platinum complexes are synthesized. The platinum complexes have both chirality and additional DNA interacting groups. The hydrogen bonding interactions in the crystal structure lead to the dimerization of two platinum complexes having pocket-like cavity with chiral shapes. Chiral ethylenediamine ligands with free tertiary amine groups and their platinum complexes are synthesized. The platinum complexes have both chirality and additional DNA interacting groups. The hydrogen bonding interactions between chlorides and two tertiary amine groups in the crystal structure lead to the dimerization of two platinum complexes having pocket-like cavity with chiral shapes.",

keywords = "Anticancer, Chiral amine, Multiple DNA interaction, Platinum",

author = "Seo, {Mi Sook} and {Soo Sohn}, Youn and Yang, {Beom Seok} and Wonwoo Nam and {Mook Kim}, Kwan",

note = "Funding Information: This work was supported by a grant from MOST through the Creative Research Initiative Program and Ewha Womans University (2004-033-1). ",

year = "2004",

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doi = "10.1016/j.inoche.2004.09.007",

language = "English",

volume = "7",

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journal = "Inorganic Chemistry Communications",

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T1 - Novel platinum complexes having chirality and free tertiary amine groups for multiple interactions with DNA

AU - Seo, Mi Sook

AU - Soo Sohn, Youn

AU - Yang, Beom Seok

AU - Nam, Wonwoo

AU - Mook Kim, Kwan

N1 - Funding Information: This work was supported by a grant from MOST through the Creative Research Initiative Program and Ewha Womans University (2004-033-1).

PY - 2004/11

Y1 - 2004/11

N2 - Chiral ethylenediamine ligands with free tertiary amine groups and their platinum complexes are synthesized. The platinum complexes have both chirality and additional DNA interacting groups. The hydrogen bonding interactions in the crystal structure lead to the dimerization of two platinum complexes having pocket-like cavity with chiral shapes. Chiral ethylenediamine ligands with free tertiary amine groups and their platinum complexes are synthesized. The platinum complexes have both chirality and additional DNA interacting groups. The hydrogen bonding interactions between chlorides and two tertiary amine groups in the crystal structure lead to the dimerization of two platinum complexes having pocket-like cavity with chiral shapes.

AB - Chiral ethylenediamine ligands with free tertiary amine groups and their platinum complexes are synthesized. The platinum complexes have both chirality and additional DNA interacting groups. The hydrogen bonding interactions in the crystal structure lead to the dimerization of two platinum complexes having pocket-like cavity with chiral shapes. Chiral ethylenediamine ligands with free tertiary amine groups and their platinum complexes are synthesized. The platinum complexes have both chirality and additional DNA interacting groups. The hydrogen bonding interactions between chlorides and two tertiary amine groups in the crystal structure lead to the dimerization of two platinum complexes having pocket-like cavity with chiral shapes.

KW - Anticancer

KW - Chiral amine

KW - Multiple DNA interaction

KW - Platinum

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DO - 10.1016/j.inoche.2004.09.007

M3 - Article

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SN - 1387-7003

VL - 7

SP - 1178

EP - 1180

JO - Inorganic Chemistry Communications

JF - Inorganic Chemistry Communications

IS - 11

ER -

Novel platinum complexes having chirality and free tertiary amine groups for multiple interactions with DNA

Abstract

Bibliographical note

Keywords

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