Novel platinum complexes having chirality and free tertiary amine groups for multiple interactions with DNA

Mi Sook Seo, Youn Soo Sohn, Beom Seok Yang, Wonwoo Nam, Kwan Mook Kim

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Chiral ethylenediamine ligands with free tertiary amine groups and their platinum complexes are synthesized. The platinum complexes have both chirality and additional DNA interacting groups. The hydrogen bonding interactions in the crystal structure lead to the dimerization of two platinum complexes having pocket-like cavity with chiral shapes. Chiral ethylenediamine ligands with free tertiary amine groups and their platinum complexes are synthesized. The platinum complexes have both chirality and additional DNA interacting groups. The hydrogen bonding interactions between chlorides and two tertiary amine groups in the crystal structure lead to the dimerization of two platinum complexes having pocket-like cavity with chiral shapes.

Original languageEnglish
Pages (from-to)1178-1180
Number of pages3
JournalInorganic Chemistry Communications
Volume7
Issue number11
DOIs
StatePublished - Nov 2004

Keywords

  • Anticancer
  • Chiral amine
  • Multiple DNA interaction
  • Platinum

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