Novel Immunomodulatory Approaches for Porcine Islet Xenotransplantation

So Hee Hong, Hyun Je Kim, Seong Jun Kang, Chung Gyu Park

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Purpose of Review: Porcine islet xenotransplantation is a promising alternative to overcome the shortage of organ donors. For the successful application of islet xenotransplantation, robust immune/inflammatory responses against porcine islets should be thoroughly controlled. Over the last few decades, there have been numerous attempts to surmount xenogeneic immune barriers. In this review, we summarize the current progress in immunomodulatory therapy for the clinical application of porcine islet xenotransplantation. Recent Findings: Long-term graft survival of porcine islets was achieved by using anti-CD154 Ab-based regimens in a preclinical non-human primate (NHP) model. However, owing to a serious complication of thromboembolism in clinical trials, the development of an anti-CD154 Ab-sparing immunosuppressant procedure is required. The efficacy of new immunosuppressive practices that employ anti-CD40 Abs or other immunosuppressive reagents has been tested in a NHP model to realize their utility in porcine islet xenotransplantation. Summary: The recent progress in the development of immunomodulatory approaches, including the immunosuppressive regimen, which enables long-term graft survival in a pig-to-non-human primate islet xenotransplantation model, with their potential clinical applicability was reviewed.

Original languageEnglish
Article number3
JournalCurrent diabetes reports
Issue number1
StatePublished - Jan 2021

Bibliographical note

Funding Information:
C.G Park is supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (Project No. HI13C0954) and also supported by a grant from National Research Foundation of Korea(NRF) grant funded by the Korea government(MSIT) (Grant No. 2019R1A2C2085287).

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.


  • Immune rejection
  • Immunosuppressant
  • Islet xenotransplantation
  • Porcine islet


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