Novel germline mutation of BRCA1 gene in a 56-Year-Old woman with breast cancer, ovarian cancer, and diffuse large B-Cell Lymphoma

Hye Sook Kim; Soon Wook Lee; Yoon Ji Choi; Sang Won Shin; Yeul Hong Kim; Min Sun Cho; Soon Nam Lee; Kyong Hwa Park

doi:10.4143/crt.2013.151

Novel germline mutation of BRCA1 gene in a 56-Year-Old woman with breast cancer, ovarian cancer, and diffuse large B-Cell Lymphoma

Hye Sook Kim, Soon Wook Lee, Yoon Ji Choi, Sang Won Shin, Yeul Hong Kim, Min Sun Cho, Soon Nam Lee, Kyong Hwa Park

Department of Pathology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We report a case of a 56-year-old woman with breast cancer, ovarian cancer, and diffuse large B-cell lymphoma with a BRCA1 gene mutation. Evidence is mounting that there is a large increase in the risk for hematologic malignancies among patients with genetic changes in the BRCA pathways. The genomic analysis demonstrated a frameshift mutation in the BRCA1 gene: 277_279delinsCC (Phe93fs). It is a novel BRCA1 mutation that has never been reported, and caused malignant lymphoma as well as breast and ovarian cancer.

Original language	English
Pages (from-to)	534-538
Number of pages	5
Journal	Cancer Research and Treatment
Volume	47
Issue number	3
DOIs	https://doi.org/10.4143/crt.2013.151
State	Published - 2015

Bibliographical note

Publisher Copyright:
© 2015 by the Korean Cancer Association.

Keywords

BRCA1 gene
Breast neoplasms
Lymphoma
Ovarian neoplasms

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10.4143/crt.2013.151

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abstract = "We report a case of a 56-year-old woman with breast cancer, ovarian cancer, and diffuse large B-cell lymphoma with a BRCA1 gene mutation. Evidence is mounting that there is a large increase in the risk for hematologic malignancies among patients with genetic changes in the BRCA pathways. The genomic analysis demonstrated a frameshift mutation in the BRCA1 gene: 277_279delinsCC (Phe93fs). It is a novel BRCA1 mutation that has never been reported, and caused malignant lymphoma as well as breast and ovarian cancer.",

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AU - Kim, Hye Sook

AU - Lee, Soon Wook

AU - Choi, Yoon Ji

AU - Shin, Sang Won

AU - Kim, Yeul Hong

AU - Cho, Min Sun

AU - Lee, Soon Nam

AU - Park, Kyong Hwa

PY - 2015

Y1 - 2015

N2 - We report a case of a 56-year-old woman with breast cancer, ovarian cancer, and diffuse large B-cell lymphoma with a BRCA1 gene mutation. Evidence is mounting that there is a large increase in the risk for hematologic malignancies among patients with genetic changes in the BRCA pathways. The genomic analysis demonstrated a frameshift mutation in the BRCA1 gene: 277_279delinsCC (Phe93fs). It is a novel BRCA1 mutation that has never been reported, and caused malignant lymphoma as well as breast and ovarian cancer.

AB - We report a case of a 56-year-old woman with breast cancer, ovarian cancer, and diffuse large B-cell lymphoma with a BRCA1 gene mutation. Evidence is mounting that there is a large increase in the risk for hematologic malignancies among patients with genetic changes in the BRCA pathways. The genomic analysis demonstrated a frameshift mutation in the BRCA1 gene: 277_279delinsCC (Phe93fs). It is a novel BRCA1 mutation that has never been reported, and caused malignant lymphoma as well as breast and ovarian cancer.

KW - BRCA1 gene

KW - Breast neoplasms

KW - Lymphoma

KW - Ovarian neoplasms

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VL - 47

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JO - Cancer Research and Treatment

JF - Cancer Research and Treatment

IS - 3

ER -

Novel germline mutation of BRCA1 gene in a 56-Year-Old woman with breast cancer, ovarian cancer, and diffuse large B-Cell Lymphoma

Abstract

Bibliographical note

Keywords

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