Nonheme FeIVO Complexes That Can Oxidize the C-H Bonds of Cyclohexane at Room Temperature

József Kaizer, Eric J. Klinker, Na Young Oh, Jan Uwe Rohde, Woon Ju Song, Audria Stubna, Jinheung Kim, Eckard Münck, Wonwoo Nam, Lawrence Que

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Nonheme oxoiron(IV) complexes of two pentadentate ligands, N4Py (N,N-bis(2-pyridylmethyl)-bis(2-pyridyl)methylamine) and Bn-tpen (N-benzyl-N,N′,N′-tris(2-pyridylmethyl)-1,2-diaminoethane), have been generated and found to have spectroscopic properties similar to the closely related tetradentate TPA (tris(2-pyridylmethyl)amine) complex reported earlier. However, unlike the TPA complex, the pentadentate complexes have a considerable lifetime at room temperature. This greater thermal stability has allowed the hydroxylation of alkanes with C-H bonds as strong as 99.3 kcal/mol to be observed at room temperature. Furthermore, a large deuterium KIE value is found in the oxidation of ethylbenzene. These observations lend strong credence to postulated mechanisms of mononuclear nonheme iron enzymes that invoke the intermediacy of oxoiron(IV) species.

Original languageEnglish
Pages (from-to)472-473
Number of pages2
JournalJournal of the American Chemical Society
Issue number2
StatePublished - 21 Jan 2004


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