Nonenzymatic amperometric sensor for ascorbic acid based on hollow gold/ruthenium nanoshells

Ara Jo; Minkyung Kang; Areum Cha; Hye Su Jang; Jun Ho Shim; Nam Suk Lee; Myung Hwa Kim; Youngmi Lee; Chongmok Lee

doi:10.1016/j.aca.2014.02.017

Nonenzymatic amperometric sensor for ascorbic acid based on hollow gold/ruthenium nanoshells

Ara Jo, Minkyung Kang, Areum Cha, Hye Su Jang, Jun Ho Shim, Nam Suk Lee, Myung Hwa Kim, Youngmi Lee, Chongmok Lee

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

We report a new nonenzymatic amperometric detection of ascorbic acid (AA) using a glassy carbon (GC) disk electrode modified with hollow gold/ruthenium (hAu-Ru) nanoshells, which exhibited decent sensing characteristics. The hAu-Ru nanoshells were prepared by the incorporation of Ru on hollow gold (hAu) nanoshells from Co nanoparticle templates, which enabled AA selectivity against glucose without aid of enzyme or membrane. The structure and electrocatalytic activities of the hAu-Ru catalysts were characterized by spectroscopic and electrochemical techniques. The hAu-Ru loaded on GC electrode (hAu-Ru/GC) showed sensitivity of 426μAmM^-1cm^-2 (normalized to the GC disk area) for the linear dynamic range of <5μM to 2mM AA at physiological pH. The response time and detection limit were 1.6s and 2.2μM, respectively. Furthermore, the hAu-Ru/GC electrode displayed remarkable selectivity for ascorbic acid over all potential biological interferents, including glucose, uric acid (UA), dopamine (DA), 4-acetamidophenol (AP), and nicotinamide adenine dinucleotide (NADH), which could be especially good for biological sensing.

Original language	English
Pages (from-to)	94-101
Number of pages	8
Journal	Analytica Chimica Acta
Volume	819
DOIs	https://doi.org/10.1016/j.aca.2014.02.017
State	Published - 28 Mar 2014

Bibliographical note

Funding Information:
This research was supported by Basic Science Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. 2013-020688 for CL and No. 2011-0015619 for YL).

Keywords

Amperometric sensor
Biosensor
Electrocatalyst
Hollow gold ruthenium
Nonenzymatic ascorbic acid sensor

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title = "Nonenzymatic amperometric sensor for ascorbic acid based on hollow gold/ruthenium nanoshells",

abstract = "We report a new nonenzymatic amperometric detection of ascorbic acid (AA) using a glassy carbon (GC) disk electrode modified with hollow gold/ruthenium (hAu-Ru) nanoshells, which exhibited decent sensing characteristics. The hAu-Ru nanoshells were prepared by the incorporation of Ru on hollow gold (hAu) nanoshells from Co nanoparticle templates, which enabled AA selectivity against glucose without aid of enzyme or membrane. The structure and electrocatalytic activities of the hAu-Ru catalysts were characterized by spectroscopic and electrochemical techniques. The hAu-Ru loaded on GC electrode (hAu-Ru/GC) showed sensitivity of 426μAmM-1cm-2 (normalized to the GC disk area) for the linear dynamic range of <5μM to 2mM AA at physiological pH. The response time and detection limit were 1.6s and 2.2μM, respectively. Furthermore, the hAu-Ru/GC electrode displayed remarkable selectivity for ascorbic acid over all potential biological interferents, including glucose, uric acid (UA), dopamine (DA), 4-acetamidophenol (AP), and nicotinamide adenine dinucleotide (NADH), which could be especially good for biological sensing.",

keywords = "Amperometric sensor, Biosensor, Electrocatalyst, Hollow gold ruthenium, Nonenzymatic ascorbic acid sensor",

author = "Ara Jo and Minkyung Kang and Areum Cha and Jang, {Hye Su} and Shim, {Jun Ho} and Lee, {Nam Suk} and Kim, {Myung Hwa} and Youngmi Lee and Chongmok Lee",

note = "Funding Information: This research was supported by Basic Science Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. 2013-020688 for CL and No. 2011-0015619 for YL). ",

year = "2014",

month = mar,

day = "28",

doi = "10.1016/j.aca.2014.02.017",

language = "English",

volume = "819",

pages = "94--101",

journal = "Analytica Chimica Acta",

issn = "0003-2670",

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T1 - Nonenzymatic amperometric sensor for ascorbic acid based on hollow gold/ruthenium nanoshells

AU - Jo, Ara

AU - Kang, Minkyung

AU - Cha, Areum

AU - Jang, Hye Su

AU - Shim, Jun Ho

AU - Lee, Nam Suk

AU - Kim, Myung Hwa

AU - Lee, Youngmi

AU - Lee, Chongmok

N1 - Funding Information: This research was supported by Basic Science Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. 2013-020688 for CL and No. 2011-0015619 for YL).

PY - 2014/3/28

Y1 - 2014/3/28

N2 - We report a new nonenzymatic amperometric detection of ascorbic acid (AA) using a glassy carbon (GC) disk electrode modified with hollow gold/ruthenium (hAu-Ru) nanoshells, which exhibited decent sensing characteristics. The hAu-Ru nanoshells were prepared by the incorporation of Ru on hollow gold (hAu) nanoshells from Co nanoparticle templates, which enabled AA selectivity against glucose without aid of enzyme or membrane. The structure and electrocatalytic activities of the hAu-Ru catalysts were characterized by spectroscopic and electrochemical techniques. The hAu-Ru loaded on GC electrode (hAu-Ru/GC) showed sensitivity of 426μAmM-1cm-2 (normalized to the GC disk area) for the linear dynamic range of <5μM to 2mM AA at physiological pH. The response time and detection limit were 1.6s and 2.2μM, respectively. Furthermore, the hAu-Ru/GC electrode displayed remarkable selectivity for ascorbic acid over all potential biological interferents, including glucose, uric acid (UA), dopamine (DA), 4-acetamidophenol (AP), and nicotinamide adenine dinucleotide (NADH), which could be especially good for biological sensing.

AB - We report a new nonenzymatic amperometric detection of ascorbic acid (AA) using a glassy carbon (GC) disk electrode modified with hollow gold/ruthenium (hAu-Ru) nanoshells, which exhibited decent sensing characteristics. The hAu-Ru nanoshells were prepared by the incorporation of Ru on hollow gold (hAu) nanoshells from Co nanoparticle templates, which enabled AA selectivity against glucose without aid of enzyme or membrane. The structure and electrocatalytic activities of the hAu-Ru catalysts were characterized by spectroscopic and electrochemical techniques. The hAu-Ru loaded on GC electrode (hAu-Ru/GC) showed sensitivity of 426μAmM-1cm-2 (normalized to the GC disk area) for the linear dynamic range of <5μM to 2mM AA at physiological pH. The response time and detection limit were 1.6s and 2.2μM, respectively. Furthermore, the hAu-Ru/GC electrode displayed remarkable selectivity for ascorbic acid over all potential biological interferents, including glucose, uric acid (UA), dopamine (DA), 4-acetamidophenol (AP), and nicotinamide adenine dinucleotide (NADH), which could be especially good for biological sensing.

KW - Amperometric sensor

KW - Biosensor

KW - Electrocatalyst

KW - Hollow gold ruthenium

KW - Nonenzymatic ascorbic acid sensor

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SN - 0003-2670

VL - 819

SP - 94

EP - 101

JO - Analytica Chimica Acta

JF - Analytica Chimica Acta

ER -

Nonenzymatic amperometric sensor for ascorbic acid based on hollow gold/ruthenium nanoshells

Abstract

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Keywords

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