Nonenzymatic amperometric sensor for ascorbic acid based on hollow gold/ruthenium nanoshells

Ara Jo, Minkyung Kang, Areum Cha, Hye Su Jang, Jun Ho Shim, Nam Suk Lee, Myung Hwa Kim, Youngmi Lee, Chongmok Lee

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We report a new nonenzymatic amperometric detection of ascorbic acid (AA) using a glassy carbon (GC) disk electrode modified with hollow gold/ruthenium (hAu-Ru) nanoshells, which exhibited decent sensing characteristics. The hAu-Ru nanoshells were prepared by the incorporation of Ru on hollow gold (hAu) nanoshells from Co nanoparticle templates, which enabled AA selectivity against glucose without aid of enzyme or membrane. The structure and electrocatalytic activities of the hAu-Ru catalysts were characterized by spectroscopic and electrochemical techniques. The hAu-Ru loaded on GC electrode (hAu-Ru/GC) showed sensitivity of 426μAmM-1cm-2 (normalized to the GC disk area) for the linear dynamic range of <5μM to 2mM AA at physiological pH. The response time and detection limit were 1.6s and 2.2μM, respectively. Furthermore, the hAu-Ru/GC electrode displayed remarkable selectivity for ascorbic acid over all potential biological interferents, including glucose, uric acid (UA), dopamine (DA), 4-acetamidophenol (AP), and nicotinamide adenine dinucleotide (NADH), which could be especially good for biological sensing.

Original languageEnglish
Pages (from-to)94-101
Number of pages8
JournalAnalytica Chimica Acta
StatePublished - 28 Mar 2014

Bibliographical note

Funding Information:
This research was supported by Basic Science Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. 2013-020688 for CL and No. 2011-0015619 for YL).


  • Amperometric sensor
  • Biosensor
  • Electrocatalyst
  • Hollow gold ruthenium
  • Nonenzymatic ascorbic acid sensor


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