TY - JOUR
T1 - Nonenzymatic amperometric sensor for ascorbic acid based on hollow gold/ruthenium nanoshells
AU - Jo, Ara
AU - Kang, Minkyung
AU - Cha, Areum
AU - Jang, Hye Su
AU - Shim, Jun Ho
AU - Lee, Nam Suk
AU - Kim, Myung Hwa
AU - Lee, Youngmi
AU - Lee, Chongmok
N1 - Funding Information:
This research was supported by Basic Science Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. 2013-020688 for CL and No. 2011-0015619 for YL).
PY - 2014/3/28
Y1 - 2014/3/28
N2 - We report a new nonenzymatic amperometric detection of ascorbic acid (AA) using a glassy carbon (GC) disk electrode modified with hollow gold/ruthenium (hAu-Ru) nanoshells, which exhibited decent sensing characteristics. The hAu-Ru nanoshells were prepared by the incorporation of Ru on hollow gold (hAu) nanoshells from Co nanoparticle templates, which enabled AA selectivity against glucose without aid of enzyme or membrane. The structure and electrocatalytic activities of the hAu-Ru catalysts were characterized by spectroscopic and electrochemical techniques. The hAu-Ru loaded on GC electrode (hAu-Ru/GC) showed sensitivity of 426μAmM-1cm-2 (normalized to the GC disk area) for the linear dynamic range of <5μM to 2mM AA at physiological pH. The response time and detection limit were 1.6s and 2.2μM, respectively. Furthermore, the hAu-Ru/GC electrode displayed remarkable selectivity for ascorbic acid over all potential biological interferents, including glucose, uric acid (UA), dopamine (DA), 4-acetamidophenol (AP), and nicotinamide adenine dinucleotide (NADH), which could be especially good for biological sensing.
AB - We report a new nonenzymatic amperometric detection of ascorbic acid (AA) using a glassy carbon (GC) disk electrode modified with hollow gold/ruthenium (hAu-Ru) nanoshells, which exhibited decent sensing characteristics. The hAu-Ru nanoshells were prepared by the incorporation of Ru on hollow gold (hAu) nanoshells from Co nanoparticle templates, which enabled AA selectivity against glucose without aid of enzyme or membrane. The structure and electrocatalytic activities of the hAu-Ru catalysts were characterized by spectroscopic and electrochemical techniques. The hAu-Ru loaded on GC electrode (hAu-Ru/GC) showed sensitivity of 426μAmM-1cm-2 (normalized to the GC disk area) for the linear dynamic range of <5μM to 2mM AA at physiological pH. The response time and detection limit were 1.6s and 2.2μM, respectively. Furthermore, the hAu-Ru/GC electrode displayed remarkable selectivity for ascorbic acid over all potential biological interferents, including glucose, uric acid (UA), dopamine (DA), 4-acetamidophenol (AP), and nicotinamide adenine dinucleotide (NADH), which could be especially good for biological sensing.
KW - Amperometric sensor
KW - Biosensor
KW - Electrocatalyst
KW - Hollow gold ruthenium
KW - Nonenzymatic ascorbic acid sensor
UR - http://www.scopus.com/inward/record.url?scp=84896036615&partnerID=8YFLogxK
U2 - 10.1016/j.aca.2014.02.017
DO - 10.1016/j.aca.2014.02.017
M3 - Article
C2 - 24636416
AN - SCOPUS:84896036615
SN - 0003-2670
VL - 819
SP - 94
EP - 101
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
ER -