Noncancerous disease-targeting AIEgens

Yanhong Duo, Guanghong Luo, Wentao Zhang, Renzhi Wang, Gary Guishan Xiao, Zihuang Li, Xianming Li, Meili Chen, Juyoung Yoon, Ben Zhong Tang

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Noncancerous diseases include a wide plethora of medical conditions beyond cancer and are a major cause of mortality around the world. Despite progresses in clinical research, many puzzles about these diseases remain unanswered, and new therapies are continuously being sought. The evolution of bio-nanomedicine has enabled huge advancements in biosensing, diagnosis, bioimaging, and therapeutics. The recent development of aggregation-induced emission luminogens (AIEgens) has provided an impetus to the field of molecular bionanomaterials. Following aggregation, AIEgens show strong emission, overcoming the problems associated with the aggregation-caused quenching (ACQ) effect. They also have other unique properties, including low background interferences, high signal-to-noise ratios, photostability, and excellent biocompatibility, along with activatable aggregation-enhanced theranostic effects, which help them achieve excellent therapeutic effects as an one-for-all multimodal theranostic platform. This review provides a comprehensive overview of the overall progresses in AIEgen-based nanoplatforms for the detection, diagnosis, bioimaging, and bioimaging-guided treatment of noncancerous diseases. In addition, it details future perspectives and the potential clinical applications of these AIEgens in noncancerous diseases are also proposed. This review hopes to motivate further interest in this topic and promote ideation for the further exploration of more advanced AIEgens in a broad range of biomedical and clinical applications in patients with noncancerous diseases.

Original languageEnglish
Pages (from-to)1024-1067
Number of pages44
JournalChemical Society Reviews
Issue number3
StatePublished - 5 Jan 2023

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© 2023 The Royal Society of Chemistry.


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