Non-steroidal Anti-inflammatory Drug Enteropathy

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


While upper GI complications secondary to NSAIDs have decreased, the incidence of a non-steroidal anti-inflammatory drug (NSAID) induced enteropathy is increasing, as are its serious clinical complications. The pathogenesis of NSAID enteropathy has suggested mechanisms related to cyclooxygenase and local mucosal damage including “three-hit hypothesis.” Symptoms of NSAID enteropathy are usually non-specific, but complications such as iron deficiency anemia, protein-losing enteropathy, and diaphragm-like strictures are possible. In rare cases, this enteropathy may cause life-threatening hemorrhage, intestinal obstruction, and perforation. Therefore, a careful history of taking NSAIDs and aggressive small bowel examination of suspected patients is required. There are no standard treatments at present; however, selective COX-2 inhibitors, mucosal protective agents (e.g., rebamipide), antibiotics, and probiotics are reported to be useful.

Original languageEnglish
Title of host publicationSmall Intestine Disease
Subtitle of host publicationA Comprehensive Guide to Diagnosis and Management
PublisherSpringer Nature
Number of pages7
ISBN (Electronic)9789811672392
ISBN (Print)9789811672385
StatePublished - 1 Jan 2022

Bibliographical note

Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2022.


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