Nodal marginal zone B-cell lymphoma: Analysis of 36 cases. Clinical presentation and treatment outcomes of nodal marginal zone B-cell lymphoma

Sung Yong Oh, Baek Yeol Ryoo, Won Seog Kim, Kihyun Kim, Jeeyun Lee, Hyun Jung Kim, Jung Mi Kwon, Hyo Rak Lee, Young Hye Ko, Suk Joong Oh, Keon Woo Park, Hyo Jin Kim, Hyuk Chan Kwon, Eunmi Nam, Jung Han Kim, Y. H.Yeon Hee Park, Seung Sook Lee, Ho Young Kim, Keunchil Park

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37 Scopus citations

Abstract

Nodal marginal zone B-cell lymphoma (NMZL) is a relatively uncommon type of lymphoma. Because of the rarity, the natural history and the optimal treatment modality have not been well defined. Therefore, we performed a retrospective analysis of the clinical features and treatment outcomes of NMZL. Thirty-six patients who were histologically diagnosed as NMZL were included in the analysis. Fifty-three percent of the patients had localized disease (stages I and II), and 21.2% (7/33) had bone marrow involvement at presentation. B symptom was present in only three patients (8.3%). Most patients were categorized as low or low-intermediate risk group by international prognostic index (IPI) (77.1%). Majority (94.4%) of the patients with localized disease achieved complete remission (CR) after the initial treatment. Of the seven patients with disseminated disease, who were treated with anthracycline-based chemotherapy, four patients achieved CR. Of the seven patients who received nonanthracycline-based chemotherapy, no patient achieved CR. After the median follow-up duration of 36 months, the median progression-free survival (PFS) was 3.9 (95% CI; 2.9-5.6) years, and the estimated 5-year PFS and overall survival rates were 47.2 and 82.7%, respectively. The significant predictive factors for PFS were performance status, advanced stage, and follicular lymphoma IPI (FLIPI) in this study. This clinical feature is similar to FL rather than to MZL-MALT type.

Original languageEnglish
Pages (from-to)781-786
Number of pages6
JournalAnnals of Hematology
Volume85
Issue number11
DOIs
StatePublished - Nov 2006

Keywords

  • Marginal zone B-cell lymphoma
  • Nodal

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