Nocarimidazoles A and B from a Marine-Derived Actinomycete of the Genus Nocardiopsis

Alain S. Leutou; Inho Yang; Heonjoong Kang; Eun Kyung Seo; Sang Jip Nam; William Fenical

doi:10.1021/acs.jnatprod.5b00746

Nocarimidazoles A and B from a Marine-Derived Actinomycete of the Genus Nocardiopsis

Alain S. Leutou, Inho Yang, Heonjoong Kang, Eun Kyung Seo, Sang Jip Nam, William Fenical

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33 Scopus citations

Abstract

Chemical investigation of a marine-derived actinomycete isolated from marine sediments collected off the coast of southern California and identified as a Nocardiopsis sp. (strain CNQ115) led to the isolation of two new 4-aminoimidazole alkaloids, nocarimidazoles A (1) and B (2). The chemical structures of nocarimidazoles A and B were assigned by interpretation of NMR spectroscopic data and through methylation to yield monomethyl and dimethyl derivatives. Nocarimidazoles A and B possess a 4-aminoimidazole ring combined with a conjugated carbonyl side chain, which is rarely found in microbial secondary metabolites.

Original language	English
Pages (from-to)	2846-2849
Number of pages	4
Journal	Journal of Natural Products
Volume	78
Issue number	11
DOIs	https://doi.org/10.1021/acs.jnatprod.5b00746
State	Published - 25 Nov 2015

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Publisher Copyright:
© 2015 The American Chemical Society and American Society of Pharmacognosy.

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abstract = "Chemical investigation of a marine-derived actinomycete isolated from marine sediments collected off the coast of southern California and identified as a Nocardiopsis sp. (strain CNQ115) led to the isolation of two new 4-aminoimidazole alkaloids, nocarimidazoles A (1) and B (2). The chemical structures of nocarimidazoles A and B were assigned by interpretation of NMR spectroscopic data and through methylation to yield monomethyl and dimethyl derivatives. Nocarimidazoles A and B possess a 4-aminoimidazole ring combined with a conjugated carbonyl side chain, which is rarely found in microbial secondary metabolites.",

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AU - Leutou, Alain S.

AU - Yang, Inho

AU - Kang, Heonjoong

AU - Seo, Eun Kyung

AU - Nam, Sang Jip

AU - Fenical, William

PY - 2015/11/25

Y1 - 2015/11/25

N2 - Chemical investigation of a marine-derived actinomycete isolated from marine sediments collected off the coast of southern California and identified as a Nocardiopsis sp. (strain CNQ115) led to the isolation of two new 4-aminoimidazole alkaloids, nocarimidazoles A (1) and B (2). The chemical structures of nocarimidazoles A and B were assigned by interpretation of NMR spectroscopic data and through methylation to yield monomethyl and dimethyl derivatives. Nocarimidazoles A and B possess a 4-aminoimidazole ring combined with a conjugated carbonyl side chain, which is rarely found in microbial secondary metabolites.

AB - Chemical investigation of a marine-derived actinomycete isolated from marine sediments collected off the coast of southern California and identified as a Nocardiopsis sp. (strain CNQ115) led to the isolation of two new 4-aminoimidazole alkaloids, nocarimidazoles A (1) and B (2). The chemical structures of nocarimidazoles A and B were assigned by interpretation of NMR spectroscopic data and through methylation to yield monomethyl and dimethyl derivatives. Nocarimidazoles A and B possess a 4-aminoimidazole ring combined with a conjugated carbonyl side chain, which is rarely found in microbial secondary metabolites.

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Nocarimidazoles A and B from a Marine-Derived Actinomycete of the Genus Nocardiopsis

Abstract

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