Nocarimidazoles A and B from a Marine-Derived Actinomycete of the Genus Nocardiopsis

Alain S. Leutou, Inho Yang, Heonjoong Kang, Eun Kyung Seo, Sang Jip Nam, William Fenical

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24 Scopus citations

Abstract

Chemical investigation of a marine-derived actinomycete isolated from marine sediments collected off the coast of southern California and identified as a Nocardiopsis sp. (strain CNQ115) led to the isolation of two new 4-aminoimidazole alkaloids, nocarimidazoles A (1) and B (2). The chemical structures of nocarimidazoles A and B were assigned by interpretation of NMR spectroscopic data and through methylation to yield monomethyl and dimethyl derivatives. Nocarimidazoles A and B possess a 4-aminoimidazole ring combined with a conjugated carbonyl side chain, which is rarely found in microbial secondary metabolites.

Original languageEnglish
Pages (from-to)2846-2849
Number of pages4
JournalJournal of Natural Products
Volume78
Issue number11
DOIs
StatePublished - 25 Nov 2015

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