Nocardiamides A and B, two cyclohexapeptides from the marine-derived actinomycete Nocardiopsis sp. CNX037

Zheng Chao Wu, Sumei Li, Sang Jip Nam, Zhong Liu, Changsheng Zhang

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Two new cyclic hexapeptides, nocardiamides A (1) and B (2), were isolated from the culture broth of marine-derived actinomycete CNX037 strain that was identified as a Nocardiopsis species. The planar structures of nocardiamides A (1) and B (2) were assigned on the basis of 1D and 2D NMR and HRESIMS spectroscopic analyses. Their absolute configurations were deduced by the advanced Marfey's method and chiral-phase HPLC analysis. The challenge of locating two d- and one l-valine residue in 1 and 2 was accomplished by total synthesis using solid-phase peptide synthetic methods. Both 1 and 2 showed negligible antimicrobial activities against seven indicator strains and exhibited no cytotoxicity against HCT-116.

Original languageEnglish
Pages (from-to)694-701
Number of pages8
JournalJournal of Natural Products
Volume76
Issue number4
DOIs
StatePublished - 26 Apr 2013

Fingerprint

Dive into the research topics of 'Nocardiamides A and B, two cyclohexapeptides from the marine-derived actinomycete Nocardiopsis sp. CNX037'. Together they form a unique fingerprint.

Cite this