Noble metal nanoparticles in DNA detection and delivery

Xi Jun Chen, Brenda L. Sanchez-Gaytan, Zhaoxia Qian, So Jung Park

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations

Abstract

DNA-conjugated metal nanoparticles have attracted enormous attention for biological and medical applications, owing to their unusual DNA melting characteristics as well as unique optical and catalytic properties. The combination of these unique properties has not only led to the development of DNA-detection technologies with remarkably high selectivity and sensitivity, but also to the development of gene therapeutic agents with high efficacy and efficiency. In this review, we present a comprehensive coverage on their applications in detecting, manipulating, and delivering genes.

Original languageEnglish
Pages (from-to)273-290
Number of pages18
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Volume4
Issue number3
DOIs
StatePublished - May 2012

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