Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics

Bum Ju Ahn; Hoang Le; Min Wook Shin; Sung Jin Bae; Eun Ji Lee; Sung Yi Lee; Ju Hee Yang; Hee Jun Wee; Jong Ho Cha; Ji Hae Seo; Hye Shin Lee; Hyo Jong Lee; Ken Arai; Eng H. Lo; Sejin Jeon; Goo Taeg Oh; Woo Jean Kim; Ji Kan Ryu; Jun Kyu Suh; Kyu Won Kim

doi:10.1074/jbc.M113.532358

Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics

Bum Ju Ahn
, Hoang Le
, Min Wook Shin
, Sung Jin Bae
, Eun Ji Lee
, Sung Yi Lee
, Ju Hee Yang
, Hee Jun Wee
, Jong Ho Cha
, Ji Hae Seo
, Hye Shin Lee
, Hyo Jong Lee
, Ken Arai
, Eng H. Lo
, Sejin Jeon
, Goo Taeg Oh
, Woo Jean Kim
, Ji Kan Ryu
, Jun Kyu Suh
, Kyu Won Kim

Department of Life Science

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Background: Ninjurin1 promotes leukocyte trafficking during inflammation through homotypic binding. Results: Changes in Ninjurin1 expression in macrophages regulate protrusive membrane dynamics, motility, and in turn transendothelial migration. Conclusion: The pro-migratory function and binding activity of Ninjurin1 are important for modulating immune responses during inflammation. Significance: This study provides additional insights into the understanding of Ninjurin1-mediated inflammation.

Original language	English
Pages (from-to)	21926-21936
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M113.532358
State	Published - 8 Aug 2014

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Ahn, B. J., Le, H., Shin, M. W., Bae, S. J., Lee, E. J., Lee, S. Y., Yang, J. H., Wee, H. J., Cha, J. H., Seo, J. H., Lee, H. S., Lee, H. J., Arai, K., Lo, E. H., Jeon, S., Oh, G. T., Kim, W. J., Ryu, J. K., Suh, J. K., & Kim, K. W. (2014). Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics. Journal of Biological Chemistry, 289(32), 21926-21936. https://doi.org/10.1074/jbc.M113.532358

@article{27c03ad6462d47a2bca6cd697e74d4b6,

title = "Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics",

abstract = "Background: Ninjurin1 promotes leukocyte trafficking during inflammation through homotypic binding. Results: Changes in Ninjurin1 expression in macrophages regulate protrusive membrane dynamics, motility, and in turn transendothelial migration. Conclusion: The pro-migratory function and binding activity of Ninjurin1 are important for modulating immune responses during inflammation. Significance: This study provides additional insights into the understanding of Ninjurin1-mediated inflammation.",

author = "Ahn, \{Bum Ju\} and Hoang Le and Shin, \{Min Wook\} and Bae, \{Sung Jin\} and Lee, \{Eun Ji\} and Lee, \{Sung Yi\} and Yang, \{Ju Hee\} and Wee, \{Hee Jun\} and Cha, \{Jong Ho\} and Seo, \{Ji Hae\} and Lee, \{Hye Shin\} and Lee, \{Hyo Jong\} and Ken Arai and Lo, \{Eng H.\} and Sejin Jeon and Oh, \{Goo Taeg\} and Kim, \{Woo Jean\} and Ryu, \{Ji Kan\} and Suh, \{Jun Kyu\} and Kim, \{Kyu Won\}",

year = "2014",

month = aug,

day = "8",

doi = "10.1074/jbc.M113.532358",

language = "English",

volume = "289",

pages = "21926--21936",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "32",

}

Ahn, BJ, Le, H, Shin, MW, Bae, SJ, Lee, EJ, Lee, SY, Yang, JH, Wee, HJ, Cha, JH, Seo, JH, Lee, HS, Lee, HJ, Arai, K, Lo, EH, Jeon, S, Oh, GT, Kim, WJ, Ryu, JK, Suh, JK & Kim, KW 2014, 'Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics', Journal of Biological Chemistry, vol. 289, no. 32, pp. 21926-21936. https://doi.org/10.1074/jbc.M113.532358

TY - JOUR

T1 - Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics

AU - Ahn, Bum Ju

AU - Le, Hoang

AU - Shin, Min Wook

AU - Bae, Sung Jin

AU - Lee, Eun Ji

AU - Lee, Sung Yi

AU - Yang, Ju Hee

AU - Wee, Hee Jun

AU - Cha, Jong Ho

AU - Seo, Ji Hae

AU - Lee, Hye Shin

AU - Lee, Hyo Jong

AU - Arai, Ken

AU - Lo, Eng H.

AU - Jeon, Sejin

AU - Oh, Goo Taeg

AU - Kim, Woo Jean

AU - Ryu, Ji Kan

AU - Suh, Jun Kyu

AU - Kim, Kyu Won

PY - 2014/8/8

Y1 - 2014/8/8

N2 - Background: Ninjurin1 promotes leukocyte trafficking during inflammation through homotypic binding. Results: Changes in Ninjurin1 expression in macrophages regulate protrusive membrane dynamics, motility, and in turn transendothelial migration. Conclusion: The pro-migratory function and binding activity of Ninjurin1 are important for modulating immune responses during inflammation. Significance: This study provides additional insights into the understanding of Ninjurin1-mediated inflammation.

AB - Background: Ninjurin1 promotes leukocyte trafficking during inflammation through homotypic binding. Results: Changes in Ninjurin1 expression in macrophages regulate protrusive membrane dynamics, motility, and in turn transendothelial migration. Conclusion: The pro-migratory function and binding activity of Ninjurin1 are important for modulating immune responses during inflammation. Significance: This study provides additional insights into the understanding of Ninjurin1-mediated inflammation.

UR - https://www.scopus.com/pages/publications/84905844122

U2 - 10.1074/jbc.M113.532358

DO - 10.1074/jbc.M113.532358

M3 - Article

C2 - 24917672

AN - SCOPUS:84905844122

SN - 0021-9258

VL - 289

SP - 21926

EP - 21936

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 32

ER -

Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics

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