Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics

Bum Ju Ahn, Hoang Le, Min Wook Shin, Sung Jin Bae, Eun Ji Lee, Sung Yi Lee, Ju Hee Yang, Hee Jun Wee, Jong Ho Cha, Ji Hae Seo, Hye Shin Lee, Hyo Jong Lee, Ken Arai, Eng H. Lo, Sejin Jeon, Goo Taeg Oh, Woo Jean Kim, Ji Kan Ryu, Jun Kyu Suh, Kyu Won Kim

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Background: Ninjurin1 promotes leukocyte trafficking during inflammation through homotypic binding. Results: Changes in Ninjurin1 expression in macrophages regulate protrusive membrane dynamics, motility, and in turn transendothelial migration. Conclusion: The pro-migratory function and binding activity of Ninjurin1 are important for modulating immune responses during inflammation. Significance: This study provides additional insights into the understanding of Ninjurin1-mediated inflammation.

Original languageEnglish
Pages (from-to)21926-21936
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
StatePublished - 8 Aug 2014

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