New thermogelling poly(organophosphazenes) with methoxypoly(ethylene glycol) and oligopeptide as side groups

Ji Yeon Seong; Yong Joo Jun; Byeongmoon Jeong; Youn Soo Sohn

doi:10.1016/j.polymer.2005.04.024

New thermogelling poly(organophosphazenes) with methoxypoly(ethylene glycol) and oligopeptide as side groups

Ji Yeon Seong, Yong Joo Jun, Byeongmoon Jeong, Youn Soo Sohn

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

A new class of thermogelling poly(organophosphazenes) bearing a hydrophilic methoxypoly(ethylene glycol) (MPEG) and a hydrophobic tri or tetrapeptide such as GlyPheLeuEt, GlyPheIleEt, GlyLeuPheEt, and GlyPheLeuGlyEt have been synthesized and characterized by means of multinuclear (¹H, ³¹P) NMR spectroscopy, gel permeation chromatography, viscometry, and elemental analysis. The gelation of the present polymers is presumed to be attributed to the intermolecular interaction between the hydrophobic oligopeptide side groups, which can form strong physical junction zones in the polymer aqueous solution. The gelation properties of the polymer were affected by the subtle change in the nature of the hydrophobic oligopeptide, composition of the hydrophilic to hydrophobic side groups, and the concentration of the polymer solutions. Among the present thermogels, the copolymer with equimolar MPEG and GlyPheIleEt as side groups showed the excellent gel phase persisting over 35-43 °C, which indicates that it is a new promising material for drug delivery and tissue engineering.

Original language	English
Pages (from-to)	5075-5081
Number of pages	7
Journal	Polymer
Volume	46
Issue number	14
DOIs	https://doi.org/10.1016/j.polymer.2005.04.024
State	Published - 27 Jun 2005

Bibliographical note

Funding Information:
This research was supported by the Ministry of Science and Technology in South Korea.

Keywords

Gel
Oligopeptide
Polyphosphazene

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10.1016/j.polymer.2005.04.024

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title = "New thermogelling poly(organophosphazenes) with methoxypoly(ethylene glycol) and oligopeptide as side groups",

abstract = "A new class of thermogelling poly(organophosphazenes) bearing a hydrophilic methoxypoly(ethylene glycol) (MPEG) and a hydrophobic tri or tetrapeptide such as GlyPheLeuEt, GlyPheIleEt, GlyLeuPheEt, and GlyPheLeuGlyEt have been synthesized and characterized by means of multinuclear (1H, 31P) NMR spectroscopy, gel permeation chromatography, viscometry, and elemental analysis. The gelation of the present polymers is presumed to be attributed to the intermolecular interaction between the hydrophobic oligopeptide side groups, which can form strong physical junction zones in the polymer aqueous solution. The gelation properties of the polymer were affected by the subtle change in the nature of the hydrophobic oligopeptide, composition of the hydrophilic to hydrophobic side groups, and the concentration of the polymer solutions. Among the present thermogels, the copolymer with equimolar MPEG and GlyPheIleEt as side groups showed the excellent gel phase persisting over 35-43 °C, which indicates that it is a new promising material for drug delivery and tissue engineering.",

keywords = "Gel, Oligopeptide, Polyphosphazene",

author = "Seong, {Ji Yeon} and Jun, {Yong Joo} and Byeongmoon Jeong and Sohn, {Youn Soo}",

note = "Funding Information: This research was supported by the Ministry of Science and Technology in South Korea. ",

year = "2005",

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doi = "10.1016/j.polymer.2005.04.024",

language = "English",

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T1 - New thermogelling poly(organophosphazenes) with methoxypoly(ethylene glycol) and oligopeptide as side groups

AU - Seong, Ji Yeon

AU - Jun, Yong Joo

AU - Jeong, Byeongmoon

AU - Sohn, Youn Soo

N1 - Funding Information: This research was supported by the Ministry of Science and Technology in South Korea.

PY - 2005/6/27

Y1 - 2005/6/27

N2 - A new class of thermogelling poly(organophosphazenes) bearing a hydrophilic methoxypoly(ethylene glycol) (MPEG) and a hydrophobic tri or tetrapeptide such as GlyPheLeuEt, GlyPheIleEt, GlyLeuPheEt, and GlyPheLeuGlyEt have been synthesized and characterized by means of multinuclear (1H, 31P) NMR spectroscopy, gel permeation chromatography, viscometry, and elemental analysis. The gelation of the present polymers is presumed to be attributed to the intermolecular interaction between the hydrophobic oligopeptide side groups, which can form strong physical junction zones in the polymer aqueous solution. The gelation properties of the polymer were affected by the subtle change in the nature of the hydrophobic oligopeptide, composition of the hydrophilic to hydrophobic side groups, and the concentration of the polymer solutions. Among the present thermogels, the copolymer with equimolar MPEG and GlyPheIleEt as side groups showed the excellent gel phase persisting over 35-43 °C, which indicates that it is a new promising material for drug delivery and tissue engineering.

AB - A new class of thermogelling poly(organophosphazenes) bearing a hydrophilic methoxypoly(ethylene glycol) (MPEG) and a hydrophobic tri or tetrapeptide such as GlyPheLeuEt, GlyPheIleEt, GlyLeuPheEt, and GlyPheLeuGlyEt have been synthesized and characterized by means of multinuclear (1H, 31P) NMR spectroscopy, gel permeation chromatography, viscometry, and elemental analysis. The gelation of the present polymers is presumed to be attributed to the intermolecular interaction between the hydrophobic oligopeptide side groups, which can form strong physical junction zones in the polymer aqueous solution. The gelation properties of the polymer were affected by the subtle change in the nature of the hydrophobic oligopeptide, composition of the hydrophilic to hydrophobic side groups, and the concentration of the polymer solutions. Among the present thermogels, the copolymer with equimolar MPEG and GlyPheIleEt as side groups showed the excellent gel phase persisting over 35-43 °C, which indicates that it is a new promising material for drug delivery and tissue engineering.

KW - Gel

KW - Oligopeptide

KW - Polyphosphazene

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U2 - 10.1016/j.polymer.2005.04.024

DO - 10.1016/j.polymer.2005.04.024

M3 - Article

AN - SCOPUS:19944388918

SN - 0032-3861

VL - 46

SP - 5075

EP - 5081

JO - Polymer

JF - Polymer

IS - 14

ER -

New thermogelling poly(organophosphazenes) with methoxypoly(ethylene glycol) and oligopeptide as side groups

Abstract

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Keywords

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