New RNA purine building blocks, 4'-selenopurine nucleosides: First synthesis and unusual mixture of sugar puckerings

Jinha Yu; Jin Hee Kim; Hyuk Woo Lee; Varughese Alexander; Hee Chul Ahn; Won Jun Choi; Jungwon Choi; Lak Shin Jeong

doi:10.1002/chem.201300741

New RNA purine building blocks, 4'-selenopurine nucleosides: First synthesis and unusual mixture of sugar puckerings

Jinha Yu, Jin Hee Kim, Hyuk Woo Lee, Varughese Alexander, Hee Chul Ahn, Won Jun Choi, Jungwon Choi, Lak Shin Jeong

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Writer's blocks: The first synthesis of RNA purine building blocks, 4'-selenoadenosine and 4'-selenoguanosine was achieved from D-ribose by regioisomeric rearrangement, which was confirmed by X-ray crystallography. 4'-Selenoadenosine exists in an unusual mixture of north and south conformers in the solid state.

Original language	English
Pages (from-to)	5528-5532
Number of pages	5
Journal	Chemistry - A European Journal
Volume	19
Issue number	18
DOIs	https://doi.org/10.1002/chem.201300741
State	Published - 26 Apr 2013

Keywords

RNA
X-ray crystallography
nucleic acids
nucleosides
selenonucleosides

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10.1002/chem.201300741

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abstract = "Writer's blocks: The first synthesis of RNA purine building blocks, 4'-selenoadenosine and 4'-selenoguanosine was achieved from D-ribose by regioisomeric rearrangement, which was confirmed by X-ray crystallography. 4'-Selenoadenosine exists in an unusual mixture of north and south conformers in the solid state.",

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author = "Jinha Yu and Kim, {Jin Hee} and Lee, {Hyuk Woo} and Varughese Alexander and Ahn, {Hee Chul} and Choi, {Won Jun} and Jungwon Choi and Jeong, {Lak Shin}",

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AU - Kim, Jin Hee

AU - Lee, Hyuk Woo

AU - Alexander, Varughese

AU - Ahn, Hee Chul

AU - Choi, Won Jun

AU - Choi, Jungwon

AU - Jeong, Lak Shin

PY - 2013/4/26

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KW - RNA

KW - X-ray crystallography

KW - nucleic acids

KW - nucleosides

KW - selenonucleosides

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IS - 18

ER -

New RNA purine building blocks, 4'-selenopurine nucleosides: First synthesis and unusual mixture of sugar puckerings

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Keywords

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