New RNA purine building blocks, 4'-selenopurine nucleosides: First synthesis and unusual mixture of sugar puckerings

Jinha Yu, Jin Hee Kim, Hyuk Woo Lee, Varughese Alexander, Hee Chul Ahn, Won Jun Choi, Jungwon Choi, Lak Shin Jeong

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Writer's blocks: The first synthesis of RNA purine building blocks, 4'-selenoadenosine and 4'-selenoguanosine was achieved from D-ribose by regioisomeric rearrangement, which was confirmed by X-ray crystallography. 4'-Selenoadenosine exists in an unusual mixture of north and south conformers in the solid state.

Original languageEnglish
Pages (from-to)5528-5532
Number of pages5
JournalChemistry - A European Journal
Volume19
Issue number18
DOIs
StatePublished - 26 Apr 2013

Keywords

  • nucleic acids
  • nucleosides
  • RNA
  • selenonucleosides
  • X-ray crystallography

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