New method for the preparation of (R)-carnitine

Choong Eui Song, Jae Kyun Lee, So Ha Lee, Sang gi Lee

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42 Scopus citations


A new method for the preparation of (R)-carnitine (1) has been developed from enantiomerically pure (R)-4-(trichloromethyl)-oxetan-2-one [(R)-2] which was easily obtained from the [2+2]-cycloaddition of ketene and chloral in the presence of catalytic amounts of poly(acryloyl quinidine). The key intermediate, ethyl (R)-3-hydroxy-4-chlorobutyrate[(R)-5], was prepared by ethanolysis of (R)-2 followed by selective bis-dechlorination of ethyl (R)-3-hydroxy-4,4,4-trichlorobutyrate [(R)-3].

Original languageEnglish
Pages (from-to)1063-1066
Number of pages4
JournalTetrahedron Asymmetry
Issue number5
StatePublished - May 1995

Bibliographical note

Funding Information:
Acknowledgement: This research was supported by grant from Ministry of Science and Technology in Korea.


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