TY - JOUR
T1 - New insights into syndecan-2 expression and tumourigenic activity in colon carcinoma cells
AU - Han, Innoc
AU - Park, Haein
AU - Oh, Eok Soo
N1 - Funding Information:
This work was supported by a research grant from the Ministry of Health and Welfare (02-PJ1-PG3-20905-0012). H. Park was supported by a fellowship from the Brain Korea 21 project.
PY - 2004
Y1 - 2004
N2 - Adhesion receptors play crucial roles in the neoplastic transformation of normal cells through induction of cancer-specific cellular behaviour and morphology. This implies that cancer cells likely express and utilize a distinct set of adhesion receptors during carcinogenesis. Colon cancer is an excellent model system for the study of this process, since both molecular genetic and morphological changes have been well established for this disease. We recently reported increased expression of the cell surface adhesion receptor, syndecan-2, in several colon carcinoma cell lines. Indeed, increased syndecan-2 expression was necessary for tumourigenic activity, suggesting that syndecan-2 might have value as both a new diagnostic marker and a possible therapeutic target. Here, we review recent advances in understanding the role of syndecan-2 in the carcinogenesis of colon cells, and discuss a leading role for this molecule in a new era for colon cancer treatment.
AB - Adhesion receptors play crucial roles in the neoplastic transformation of normal cells through induction of cancer-specific cellular behaviour and morphology. This implies that cancer cells likely express and utilize a distinct set of adhesion receptors during carcinogenesis. Colon cancer is an excellent model system for the study of this process, since both molecular genetic and morphological changes have been well established for this disease. We recently reported increased expression of the cell surface adhesion receptor, syndecan-2, in several colon carcinoma cell lines. Indeed, increased syndecan-2 expression was necessary for tumourigenic activity, suggesting that syndecan-2 might have value as both a new diagnostic marker and a possible therapeutic target. Here, we review recent advances in understanding the role of syndecan-2 in the carcinogenesis of colon cells, and discuss a leading role for this molecule in a new era for colon cancer treatment.
UR - http://www.scopus.com/inward/record.url?scp=14844287100&partnerID=8YFLogxK
U2 - 10.1023/B:HIJO.0000032363.78829.4e
DO - 10.1023/B:HIJO.0000032363.78829.4e
M3 - Review article
C2 - 15339051
AN - SCOPUS:14844287100
SN - 1567-2379
VL - 35
SP - 319
EP - 326
JO - Journal of Molecular Histology
JF - Journal of Molecular Histology
IS - 3
ER -