New compounds with DNA strand-scission activity from the combined leaf and stem of Uvaria hamiltonii

Li Huang, Monroe E. Wall, Mansukh C. Wani, Hernán Navarro, Thawatchai Santisuk, Vichai Reutrakul, Eun Kyoung Seo, Norman R. Farnsworth, A. Douglas Kinghorn

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Two flavanones, hamiltones A (1) and B (2), an aurone, hamiltrone (3), a chalcone, hamilcone (4), and a tetrahydroxanthene, hamilxanthene (5), were isolated from Uvaria hamiltonii extracts guided initially by fractionation based on DNA strand-scission and/or 9KB cytotoxicity assays. Compounds 2-5 have not been reported previously, while 1 is new as a natural product. Structural assignments were made based on extensive spectroscopic measurements. Compounds 1-3 were inactive in the 9KB cytotoxicity assay, with compounds 4 and 5 having weak activity. In the DNA strand-scission assay, 3 was the most active compound found in the DNA strand-scission assay, being 10 times more potent than 1 or 2. Compound 4 was only weakly active, and 5 was inactive.

Original languageEnglish
Pages (from-to)446-450
Number of pages5
JournalJournal of Natural Products
Volume61
Issue number4
DOIs
StatePublished - Apr 1998

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