New biphenyl compounds with DNA strand-scission activity from Clusia paralicola

Eun Kyoung Seo; Li Huang; Monroe E. Wall; Mansukh C. Wani; Hernan Navarro; Rabindranath Mukherjee; Norman R. Farnsworth; A. Douglas Kinghorn

doi:10.1021/np9900775

New biphenyl compounds with DNA strand-scission activity from Clusia paralicola

Eun Kyoung Seo
, Li Huang
, Monroe E. Wall
, Mansukh C. Wani
, Hernan Navarro
, Rabindranath Mukherjee
, Norman R. Farnsworth
, A. Douglas Kinghorn

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Three new biphenyl derivatives, clusiparalicolines A (1), B (2), and C (3), were isolated from the roots of Clusia paralicola by bioassay-directed fractionation using the DNA strand-scission and the KB human cancer cell line cytotoxicity assays. Compounds 1 and 2 were found to be active in the DNA strand-scission assay, whereas all three compounds exhibited modest cytotoxicity against the KB cell line. The structures of 1-3 were elucidated by spectroscopic methods including 1D and 2D NMR techniques.

Original language	English
Pages (from-to)	1484-1487
Number of pages	4
Journal	Journal of Natural Products
Volume	62
Issue number	11
DOIs	https://doi.org/10.1021/np9900775
State	Published - Nov 1999

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10.1021/np9900775

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@article{0e921a85532340cf9c66fee3b47ba507,

title = "New biphenyl compounds with DNA strand-scission activity from Clusia paralicola",

abstract = "Three new biphenyl derivatives, clusiparalicolines A (1), B (2), and C (3), were isolated from the roots of Clusia paralicola by bioassay-directed fractionation using the DNA strand-scission and the KB human cancer cell line cytotoxicity assays. Compounds 1 and 2 were found to be active in the DNA strand-scission assay, whereas all three compounds exhibited modest cytotoxicity against the KB cell line. The structures of 1-3 were elucidated by spectroscopic methods including 1D and 2D NMR techniques.",

author = "Seo, \{Eun Kyoung\} and Li Huang and Wall, \{Monroe E.\} and Wani, \{Mansukh C.\} and Hernan Navarro and Rabindranath Mukherjee and Farnsworth, \{Norman R.\} and Kinghorn, \{A. Douglas\}",

year = "1999",

month = nov,

doi = "10.1021/np9900775",

language = "English",

volume = "62",

pages = "1484--1487",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

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TY - JOUR

T1 - New biphenyl compounds with DNA strand-scission activity from Clusia paralicola

AU - Seo, Eun Kyoung

AU - Huang, Li

AU - Wall, Monroe E.

AU - Wani, Mansukh C.

AU - Navarro, Hernan

AU - Mukherjee, Rabindranath

AU - Farnsworth, Norman R.

AU - Kinghorn, A. Douglas

PY - 1999/11

Y1 - 1999/11

N2 - Three new biphenyl derivatives, clusiparalicolines A (1), B (2), and C (3), were isolated from the roots of Clusia paralicola by bioassay-directed fractionation using the DNA strand-scission and the KB human cancer cell line cytotoxicity assays. Compounds 1 and 2 were found to be active in the DNA strand-scission assay, whereas all three compounds exhibited modest cytotoxicity against the KB cell line. The structures of 1-3 were elucidated by spectroscopic methods including 1D and 2D NMR techniques.

AB - Three new biphenyl derivatives, clusiparalicolines A (1), B (2), and C (3), were isolated from the roots of Clusia paralicola by bioassay-directed fractionation using the DNA strand-scission and the KB human cancer cell line cytotoxicity assays. Compounds 1 and 2 were found to be active in the DNA strand-scission assay, whereas all three compounds exhibited modest cytotoxicity against the KB cell line. The structures of 1-3 were elucidated by spectroscopic methods including 1D and 2D NMR techniques.

UR - https://www.scopus.com/pages/publications/0032708485

U2 - 10.1021/np9900775

DO - 10.1021/np9900775

M3 - Article

C2 - 10579857

AN - SCOPUS:0032708485

SN - 0163-3864

VL - 62

SP - 1484

EP - 1487

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 11

ER -

New biphenyl compounds with DNA strand-scission activity from Clusia paralicola

Abstract

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