New biphenyl compounds with DNA strand-scission activity from Clusia paralicola

Eun Kyoung Seo, Li Huang, Monroe E. Wall, Mansukh C. Wani, Hernan Navarro, Rabindranath Mukherjee, Norman R. Farnsworth, A. Douglas Kinghorn

Research output: Contribution to journalArticlepeer-review

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Three new biphenyl derivatives, clusiparalicolines A (1), B (2), and C (3), were isolated from the roots of Clusia paralicola by bioassay-directed fractionation using the DNA strand-scission and the KB human cancer cell line cytotoxicity assays. Compounds 1 and 2 were found to be active in the DNA strand-scission assay, whereas all three compounds exhibited modest cytotoxicity against the KB cell line. The structures of 1-3 were elucidated by spectroscopic methods including 1D and 2D NMR techniques.

Original languageEnglish
Pages (from-to)1484-1487
Number of pages4
JournalJournal of Natural Products
Issue number11
StatePublished - Nov 1999


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