TY - JOUR
T1 - New biphenyl compounds with DNA strand-scission activity from Clusia paralicola
AU - Seo, Eun Kyoung
AU - Huang, Li
AU - Wall, Monroe E.
AU - Wani, Mansukh C.
AU - Navarro, Hernan
AU - Mukherjee, Rabindranath
AU - Farnsworth, Norman R.
AU - Kinghorn, A. Douglas
PY - 1999/11
Y1 - 1999/11
N2 - Three new biphenyl derivatives, clusiparalicolines A (1), B (2), and C (3), were isolated from the roots of Clusia paralicola by bioassay-directed fractionation using the DNA strand-scission and the KB human cancer cell line cytotoxicity assays. Compounds 1 and 2 were found to be active in the DNA strand-scission assay, whereas all three compounds exhibited modest cytotoxicity against the KB cell line. The structures of 1-3 were elucidated by spectroscopic methods including 1D and 2D NMR techniques.
AB - Three new biphenyl derivatives, clusiparalicolines A (1), B (2), and C (3), were isolated from the roots of Clusia paralicola by bioassay-directed fractionation using the DNA strand-scission and the KB human cancer cell line cytotoxicity assays. Compounds 1 and 2 were found to be active in the DNA strand-scission assay, whereas all three compounds exhibited modest cytotoxicity against the KB cell line. The structures of 1-3 were elucidated by spectroscopic methods including 1D and 2D NMR techniques.
UR - http://www.scopus.com/inward/record.url?scp=0032708485&partnerID=8YFLogxK
U2 - 10.1021/np9900775
DO - 10.1021/np9900775
M3 - Article
C2 - 10579857
AN - SCOPUS:0032708485
SN - 0163-3864
VL - 62
SP - 1484
EP - 1487
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 11
ER -
