New biocompatible polypyrrole-based films with good blood compatibility and high electrical conductivity

Chun Mao, Aiping Zhu, Qiong Wu, Xiangbai Chen, Jinheung Kim, Jian Shen

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

A novel O-butyryl chitosan (OBCS)-grafted polypyrrole (PPy) film was described. The immobilization was accomplished by photocrosslinking the OBCS onto PPy films under ultraviolet light irradiation. The surfaces of OBCS-grafted PPy film were characterized by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and electron spectroscopy for chemical analysis (ESCA). The blood compatibility of the OBCS-grafted PPy film was evaluated by platelet-rich plasma (PRP) contacting experiments and protein adsorption experiments in vitro. These results have demonstrated that the surface with immobilized OBCS shows much less platelet adhesive and fibrinogen adsorption compared to the control surface. The bulk conductivity values of PPy films were measured by a modified four-probe method. The composite films have both good blood compatibility and high electrical conductivity that make them suitable for using as potential biomaterials, such as electrically conducting blood vessel and functionally haemocompatible substrate of biosensor used directly in whole blood.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalColloids and Surfaces B: Biointerfaces
Volume67
Issue number1
DOIs
StatePublished - 15 Nov 2008

Keywords

  • Blood compatibility
  • Electrical conductivity
  • Fibrinogen adsorption
  • Platelet adhesion
  • Polypyrrole films

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