New bioactive aromatic compounds from Vismia guianensis

Eun Kyoung Seo, Mansukh C. Wani, Monroe E. Wall, Hernan Navarro, Rabindranath Mukherjee, Norman R. Farnsworth, A. Douglas Kinghorn

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


Five benzophenones, vismiaguianones A-E, and two benzocoumarins, vismiaguianins A and B were isolated from the CHCl3 extract of the roots of Vismia guianensis by bioassay-directed fractionation using the DNA strand-scission assay and KB cell line. Of the isolates obtained, vismiaguianone B exhibited DNA strand-scission activity, whereas vismiaguianones D and E and vismiaguianin A were found to be significantly cytotoxic. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
Issue number1
StatePublished - 20 Sep 2000


  • Benzocoumarins
  • Cytotoxic activity
  • DNA strand-scission activity
  • Guttiferae
  • Prenylated benzophenones
  • Roots
  • Vismia guianensis
  • Vismiaguianins A and B
  • Vismiaguianones A-E


Dive into the research topics of 'New bioactive aromatic compounds from Vismia guianensis'. Together they form a unique fingerprint.

Cite this