New bioactive aromatic compounds from Vismia guianensis

Eun Kyoung Seo; Mansukh C. Wani; Monroe E. Wall; Hernan Navarro; Rabindranath Mukherjee; Norman R. Farnsworth; A. Douglas Kinghorn

doi:10.1016/S0031-9422(00)00208-9

New bioactive aromatic compounds from Vismia guianensis

Eun Kyoung Seo, Mansukh C. Wani, Monroe E. Wall, Hernan Navarro, Rabindranath Mukherjee, Norman R. Farnsworth, A. Douglas Kinghorn

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Five benzophenones, vismiaguianones A-E, and two benzocoumarins, vismiaguianins A and B were isolated from the CHCl₃ extract of the roots of Vismia guianensis by bioassay-directed fractionation using the DNA strand-scission assay and KB cell line. Of the isolates obtained, vismiaguianone B exhibited DNA strand-scission activity, whereas vismiaguianones D and E and vismiaguianin A were found to be significantly cytotoxic. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	35-42
Number of pages	8
Journal	Phytochemistry
Volume	55
Issue number	1
DOIs	https://doi.org/10.1016/S0031-9422(00)00208-9
State	Published - 20 Sep 2000

Bibliographical note

Funding Information:
This investigation was supported by grant U19-CA52956 from the National Cancer Institute, NIH, Bethesda, MD. We would like to thank Dr J. Burgess for NMR experiments, and Ms S. Spaulding and Ms Y. Brackeen for technical assistance at Research Triangle Institute. Dr H. Gracz at North Carolina State University is also acknowledged for some of NMR experiments. R. Mukherjee thanks CNPq, Brazil, for financial assistance.

Keywords

Benzocoumarins
Cytotoxic activity
DNA strand-scission activity
Guttiferae
Prenylated benzophenones
Roots
Vismia guianensis
Vismiaguianins A and B
Vismiaguianones A-E

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10.1016/S0031-9422(00)00208-9

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title = "New bioactive aromatic compounds from Vismia guianensis",

abstract = "Five benzophenones, vismiaguianones A-E, and two benzocoumarins, vismiaguianins A and B were isolated from the CHCl3 extract of the roots of Vismia guianensis by bioassay-directed fractionation using the DNA strand-scission assay and KB cell line. Of the isolates obtained, vismiaguianone B exhibited DNA strand-scission activity, whereas vismiaguianones D and E and vismiaguianin A were found to be significantly cytotoxic. (C) 2000 Elsevier Science Ltd.",

keywords = "Benzocoumarins, Cytotoxic activity, DNA strand-scission activity, Guttiferae, Prenylated benzophenones, Roots, Vismia guianensis, Vismiaguianins A and B, Vismiaguianones A-E",

author = "Seo, {Eun Kyoung} and Wani, {Mansukh C.} and Wall, {Monroe E.} and Hernan Navarro and Rabindranath Mukherjee and Farnsworth, {Norman R.} and Kinghorn, {A. Douglas}",

note = "Funding Information: This investigation was supported by grant U19-CA52956 from the National Cancer Institute, NIH, Bethesda, MD. We would like to thank Dr J. Burgess for NMR experiments, and Ms S. Spaulding and Ms Y. Brackeen for technical assistance at Research Triangle Institute. Dr H. Gracz at North Carolina State University is also acknowledged for some of NMR experiments. R. Mukherjee thanks CNPq, Brazil, for financial assistance.",

year = "2000",

month = sep,

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doi = "10.1016/S0031-9422(00)00208-9",

language = "English",

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T1 - New bioactive aromatic compounds from Vismia guianensis

AU - Seo, Eun Kyoung

AU - Wani, Mansukh C.

AU - Wall, Monroe E.

AU - Navarro, Hernan

AU - Mukherjee, Rabindranath

AU - Farnsworth, Norman R.

AU - Kinghorn, A. Douglas

N1 - Funding Information: This investigation was supported by grant U19-CA52956 from the National Cancer Institute, NIH, Bethesda, MD. We would like to thank Dr J. Burgess for NMR experiments, and Ms S. Spaulding and Ms Y. Brackeen for technical assistance at Research Triangle Institute. Dr H. Gracz at North Carolina State University is also acknowledged for some of NMR experiments. R. Mukherjee thanks CNPq, Brazil, for financial assistance.

PY - 2000/9/20

Y1 - 2000/9/20

N2 - Five benzophenones, vismiaguianones A-E, and two benzocoumarins, vismiaguianins A and B were isolated from the CHCl3 extract of the roots of Vismia guianensis by bioassay-directed fractionation using the DNA strand-scission assay and KB cell line. Of the isolates obtained, vismiaguianone B exhibited DNA strand-scission activity, whereas vismiaguianones D and E and vismiaguianin A were found to be significantly cytotoxic. (C) 2000 Elsevier Science Ltd.

AB - Five benzophenones, vismiaguianones A-E, and two benzocoumarins, vismiaguianins A and B were isolated from the CHCl3 extract of the roots of Vismia guianensis by bioassay-directed fractionation using the DNA strand-scission assay and KB cell line. Of the isolates obtained, vismiaguianone B exhibited DNA strand-scission activity, whereas vismiaguianones D and E and vismiaguianin A were found to be significantly cytotoxic. (C) 2000 Elsevier Science Ltd.

KW - Benzocoumarins

KW - Cytotoxic activity

KW - DNA strand-scission activity

KW - Guttiferae

KW - Prenylated benzophenones

KW - Roots

KW - Vismia guianensis

KW - Vismiaguianins A and B

KW - Vismiaguianones A-E

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U2 - 10.1016/S0031-9422(00)00208-9

DO - 10.1016/S0031-9422(00)00208-9

M3 - Article

C2 - 11021642

AN - SCOPUS:0034692439

SN - 0031-9422

VL - 55

SP - 35

EP - 42

JO - Phytochemistry

JF - Phytochemistry

IS - 1

ER -

New bioactive aromatic compounds from Vismia guianensis

Abstract

Bibliographical note

Keywords

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