New bioactive aromatic compounds from Vismia guianensis

Eun Kyoung Seo, Mansukh C. Wani, Monroe E. Wall, Hernan Navarro, Rabindranath Mukherjee, Norman R. Farnsworth, A. Douglas Kinghorn

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

Five benzophenones, vismiaguianones A-E, and two benzocoumarins, vismiaguianins A and B were isolated from the CHCl3 extract of the roots of Vismia guianensis by bioassay-directed fractionation using the DNA strand-scission assay and KB cell line. Of the isolates obtained, vismiaguianone B exhibited DNA strand-scission activity, whereas vismiaguianones D and E and vismiaguianin A were found to be significantly cytotoxic. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalPhytochemistry
Volume55
Issue number1
DOIs
StatePublished - 20 Sep 2000

Keywords

  • Benzocoumarins
  • Cytotoxic activity
  • DNA strand-scission activity
  • Guttiferae
  • Prenylated benzophenones
  • Roots
  • Vismia guianensis
  • Vismiaguianins A and B
  • Vismiaguianones A-E

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