Five benzophenones, vismiaguianones A-E, and two benzocoumarins, vismiaguianins A and B were isolated from the CHCl3 extract of the roots of Vismia guianensis by bioassay-directed fractionation using the DNA strand-scission assay and KB cell line. Of the isolates obtained, vismiaguianone B exhibited DNA strand-scission activity, whereas vismiaguianones D and E and vismiaguianin A were found to be significantly cytotoxic. (C) 2000 Elsevier Science Ltd.
Bibliographical noteFunding Information:
This investigation was supported by grant U19-CA52956 from the National Cancer Institute, NIH, Bethesda, MD. We would like to thank Dr J. Burgess for NMR experiments, and Ms S. Spaulding and Ms Y. Brackeen for technical assistance at Research Triangle Institute. Dr H. Gracz at North Carolina State University is also acknowledged for some of NMR experiments. R. Mukherjee thanks CNPq, Brazil, for financial assistance.
- Cytotoxic activity
- DNA strand-scission activity
- Prenylated benzophenones
- Vismia guianensis
- Vismiaguianins A and B
- Vismiaguianones A-E