New acridine derivatives bearing immobilized azacrown or azathiacrown ligand as fluorescent chemosensors for Hg2+ and Cd2+

Han Na Lee, Ha Na Kim, K. M.K. Swamy, Min Sun Park, Jimi Kim, Hyunsook Lee, Keun Hyeung Lee, Sungsu Park, Juyoung Yoon

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62 Scopus citations

Abstract

Two new acridine derivatives bearing azacrown or azathiacrown ligand were synthesized as fluorescent chemosensors for Hg2+ and Cd2+ in aqueous solution. Compounds 1 and 2 displayed selective CHEF (chelation enhanced fluorescence) effects with Hg2+ or Cd2+ among the metal ions examined. The practical use of these probes was demonstrated by their applications to the detection of Hg2+ and Cd2+ ions in mammalian cells.

Original languageEnglish
Pages (from-to)1261-1265
Number of pages5
JournalTetrahedron Letters
Volume49
Issue number7
DOIs
StatePublished - 11 Feb 2008

Bibliographical note

Funding Information:
This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant (NRL) funded by the Korean government (MOST) (R04-2007-000-2007-0), Korea Ministry of Environment as ‘The Eco-technopia 21 project’ and BK21.

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