Two new acridine derivatives bearing azacrown or azathiacrown ligand were synthesized as fluorescent chemosensors for Hg2+ and Cd2+ in aqueous solution. Compounds 1 and 2 displayed selective CHEF (chelation enhanced fluorescence) effects with Hg2+ or Cd2+ among the metal ions examined. The practical use of these probes was demonstrated by their applications to the detection of Hg2+ and Cd2+ ions in mammalian cells.
Bibliographical noteFunding Information:
This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant (NRL) funded by the Korean government (MOST) (R04-2007-000-2007-0), Korea Ministry of Environment as ‘The Eco-technopia 21 project’ and BK21.