Neutrophil gelatinase-associated lipocalin as an early biomarker of acute kidney injury in liver transplantation

Tae Dong Jeong, Sollip Kim, Woochang Lee, Gi Won Song, Young Kug Kim, Sail Chun, Sung Gyu Lee, Won Ki Min

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Background: Acute kidney injury (AKI) is a common complication and a significant prognostic factor of long-term outcome in patients undergoing liver transplantation. We evaluated the utility of urine and plasma neutrophil gelatinase-associated lipocalin (NGAL) concentrations as biomarkers of AKI during and after liver transplantation. Materials and methods: We prospectively enrolled 19 adult patients who underwent living-related liver transplantation (LRLT). Serial blood and urine samples were collected at baseline and at 2, 4, 10, 16, 24, 30, 40, and 48 h after reperfusion, and their concentrations of NGAL were measured, with urinary NGAL corrected by urinary creatinine concentration to compensate for urine output. AKI was defined by Risk-Injury-Failure-Loss-End-stage kidney disease (RIFLE) criteria as a ≥50% increase in serum creatinine from baseline. Results: Eleven of 19 patients were diagnosed with AKI according to RIFLE criteria. Urinary NGAL/urine creatinine ratio increased immediately after reperfusion and peaked four h later and preceded a ≥50% elevation in serum Cr by 19.0 h (p = 0.001). Plasma NGAL also tended to be elevated 13.0 h earlier than serum creatinine (p = 0.075). Conclusions: The urinary NGAL/urine creatinine ratio may be an early biomarker of AKI in adult patients undergoing LRLT.

Original languageEnglish
Pages (from-to)775-781
Number of pages7
JournalClinical Transplantation
Volume26
Issue number5
DOIs
StatePublished - Sep 2012

Keywords

  • Acute kidney injury
  • Liver transplantation
  • NGAL

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