Neuropathogenesis-on-chips for neurodegenerative diseases

Sarnai Amartumur; Huong Nguyen; Thuy Huynh; Testaverde S. Kim; Ran Sook Woo; Eungseok Oh; Kyeong Kyu Kim; Luke P. Lee; Chaejeong Heo

doi:10.1038/s41467-024-46554-8

Neuropathogenesis-on-chips for neurodegenerative diseases

Sarnai Amartumur, Huong Nguyen, Thuy Huynh, Testaverde S. Kim, Ran Sook Woo, Eungseok Oh, Kyeong Kyu Kim, Luke P. Lee, Chaejeong Heo

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Developing diagnostics and treatments for neurodegenerative diseases (NDs) is challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro systems that recapitulate patient-like pathophysiology are emerging as alternatives to conventional animal-based models. In this review, we explore the interconnected pathogenic features of different types of ND, discuss the general strategy to modelling NDs using a microfluidic chip, and introduce the organoid-on-a-chip as the next advanced relevant model. Lastly, we overview how these models are being applied in academic and industrial drug development. The integration of microfluidic chips, stem cells, and biotechnological devices promises to provide valuable insights for biomedical research and developing diagnostic and therapeutic solutions for NDs.

Original language	English
Article number	2219
Journal	Nature Communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-46554-8
State	Published - Mar 2024

Bibliographical note

Publisher Copyright:
© The Author(s) 2024.

Access to Document

10.1038/s41467-024-46554-8

Cite this

@article{507f9eda6f184b9689a185b58c28d2bd,

title = "Neuropathogenesis-on-chips for neurodegenerative diseases",

abstract = "Developing diagnostics and treatments for neurodegenerative diseases (NDs) is challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro systems that recapitulate patient-like pathophysiology are emerging as alternatives to conventional animal-based models. In this review, we explore the interconnected pathogenic features of different types of ND, discuss the general strategy to modelling NDs using a microfluidic chip, and introduce the organoid-on-a-chip as the next advanced relevant model. Lastly, we overview how these models are being applied in academic and industrial drug development. The integration of microfluidic chips, stem cells, and biotechnological devices promises to provide valuable insights for biomedical research and developing diagnostic and therapeutic solutions for NDs.",

author = "Sarnai Amartumur and Huong Nguyen and Thuy Huynh and Kim, {Testaverde S.} and Woo, {Ran Sook} and Eungseok Oh and Kim, {Kyeong Kyu} and Lee, {Luke P.} and Chaejeong Heo",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = mar,

doi = "10.1038/s41467-024-46554-8",

language = "English",

volume = "15",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Neuropathogenesis-on-chips for neurodegenerative diseases

AU - Amartumur, Sarnai

AU - Nguyen, Huong

AU - Huynh, Thuy

AU - Kim, Testaverde S.

AU - Woo, Ran Sook

AU - Oh, Eungseok

AU - Kim, Kyeong Kyu

AU - Lee, Luke P.

AU - Heo, Chaejeong

PY - 2024/3

Y1 - 2024/3

N2 - Developing diagnostics and treatments for neurodegenerative diseases (NDs) is challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro systems that recapitulate patient-like pathophysiology are emerging as alternatives to conventional animal-based models. In this review, we explore the interconnected pathogenic features of different types of ND, discuss the general strategy to modelling NDs using a microfluidic chip, and introduce the organoid-on-a-chip as the next advanced relevant model. Lastly, we overview how these models are being applied in academic and industrial drug development. The integration of microfluidic chips, stem cells, and biotechnological devices promises to provide valuable insights for biomedical research and developing diagnostic and therapeutic solutions for NDs.

AB - Developing diagnostics and treatments for neurodegenerative diseases (NDs) is challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro systems that recapitulate patient-like pathophysiology are emerging as alternatives to conventional animal-based models. In this review, we explore the interconnected pathogenic features of different types of ND, discuss the general strategy to modelling NDs using a microfluidic chip, and introduce the organoid-on-a-chip as the next advanced relevant model. Lastly, we overview how these models are being applied in academic and industrial drug development. The integration of microfluidic chips, stem cells, and biotechnological devices promises to provide valuable insights for biomedical research and developing diagnostic and therapeutic solutions for NDs.

UR - http://www.scopus.com/inward/record.url?scp=85187721815&partnerID=8YFLogxK

U2 - 10.1038/s41467-024-46554-8

DO - 10.1038/s41467-024-46554-8

M3 - Review article

C2 - 38472255

AN - SCOPUS:85187721815

SN - 2041-1723

VL - 15

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 2219

ER -

Neuropathogenesis-on-chips for neurodegenerative diseases

Abstract

Bibliographical note

Access to Document

Fingerprint

Cite this