Neurologic signs in relation to cognitive function in subcortical ischemic vascular dementia: A CREDOS (Clinical Research Center for Dementia of South Korea) study

Seong Hye Choi; Sangyun Kim; Seol Heui Han; Duk L. Na; Doh Kwan Kim; Hae Kwan Cheong; Jae Hong Lee; Seong Yoon Kim; Chang Hyung Hong; So Young Moon; Jay C. Kwon; Jung Eun Kim; Jee H. Jeong; Hae Ri Na; Kyung Ryeol Cha; Sang Won Seo; Yong S. Shim; Jun Young Lee; Kyung Won Park

doi:10.1007/s10072-011-0845-4

Neurologic signs in relation to cognitive function in subcortical ischemic vascular dementia: A CREDOS (Clinical Research Center for Dementia of South Korea) study

Seong Hye Choi, Sangyun Kim, Seol Heui Han, Duk L. Na, Doh Kwan Kim, Hae Kwan Cheong, Jae Hong Lee, Seong Yoon Kim, Chang Hyung Hong, So Young Moon, Jay C. Kwon, Jung Eun Kim, Jee H. Jeong, Hae Ri Na, Kyung Ryeol Cha, Sang Won Seo, Yong S. Shim, Jun Young Lee, Kyung Won Park

Department of Neurology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The objective of this study was to investigate the relationship between neurologic signs and cognitive dysfunction in subcortical ischemic vascular dementia (SIVD). 121 patients with SIVD were recruited from multiple nationwide hospitals. The patients' neurologic signs were evaluated using the Focal Neurologic Sign Score (FNSS). The FNSS scores did not correlate with the composite neuropsychology scores and Korean Mini-Mental State Examination scores. The FNSS scores correlated with the letter fluency and Rey-Osterrieth Complex Figure (ROCF) copy scores.Using a multivariate regression analysis controlled for age, sex, and educational level, the FNSS scores had a significant relationship with the letter fluency test scores (R² = 0.08, b = -2.28, p = 0.02) and ROCF copy scores (R² = 0.08, b = -0.42, p = 0.03). These findings suggest that the neurologic signs in patients with SIVD do not correlate with global cognitive functions; however, these signs do correlate with executive dysfunction in these patients.

Original language	English
Pages (from-to)	839-846
Number of pages	8
Journal	Neurological Sciences
Volume	33
Issue number	4
DOIs	https://doi.org/10.1007/s10072-011-0845-4
State	Published - Aug 2012

Bibliographical note

Funding Information:
This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A102065).

Keywords

Cognition
Executive dysfunction
Neurologic sign
Small-vessel disease
Subcortical ischemic vascular dementia
White matter changes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Hye Choi, S., Kim, S., Han, S. H., Na, D. L., Kim, D. K., Cheong, H. K., Lee, J. H., Kim, S. Y., Hong, C. H., Moon, S. Y., Kwon, J. C., Kim, J. E., Jeong, J. H., Na, H. R., Cha, K. R., Seo, S. W., Shim, Y. S., Lee, J. Y., & Park, K. W. (2012). Neurologic signs in relation to cognitive function in subcortical ischemic vascular dementia: A CREDOS (Clinical Research Center for Dementia of South Korea) study. Neurological Sciences, 33(4), 839-846. https://doi.org/10.1007/s10072-011-0845-4

@article{4a33296c02034d0fb9780e1a5d68c043,

title = "Neurologic signs in relation to cognitive function in subcortical ischemic vascular dementia: A CREDOS (Clinical Research Center for Dementia of South Korea) study",

abstract = "The objective of this study was to investigate the relationship between neurologic signs and cognitive dysfunction in subcortical ischemic vascular dementia (SIVD). 121 patients with SIVD were recruited from multiple nationwide hospitals. The patients' neurologic signs were evaluated using the Focal Neurologic Sign Score (FNSS). The FNSS scores did not correlate with the composite neuropsychology scores and Korean Mini-Mental State Examination scores. The FNSS scores correlated with the letter fluency and Rey-Osterrieth Complex Figure (ROCF) copy scores.Using a multivariate regression analysis controlled for age, sex, and educational level, the FNSS scores had a significant relationship with the letter fluency test scores (R2 = 0.08, b = -2.28, p = 0.02) and ROCF copy scores (R2 = 0.08, b = -0.42, p = 0.03). These findings suggest that the neurologic signs in patients with SIVD do not correlate with global cognitive functions; however, these signs do correlate with executive dysfunction in these patients.",

keywords = "Cognition, Executive dysfunction, Neurologic sign, Small-vessel disease, Subcortical ischemic vascular dementia, White matter changes",

author = "{Hye Choi}, Seong and Sangyun Kim and Han, {Seol Heui} and Na, {Duk L.} and Kim, {Doh Kwan} and Cheong, {Hae Kwan} and Lee, {Jae Hong} and Kim, {Seong Yoon} and Hong, {Chang Hyung} and Moon, {So Young} and Kwon, {Jay C.} and Kim, {Jung Eun} and Jeong, {Jee H.} and Na, {Hae Ri} and Cha, {Kyung Ryeol} and Seo, {Sang Won} and Shim, {Yong S.} and Lee, {Jun Young} and Park, {Kyung Won}",

note = "Funding Information: This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A102065).",

year = "2012",

month = aug,

doi = "10.1007/s10072-011-0845-4",

language = "English",

volume = "33",

pages = "839--846",

journal = "Neurological Sciences",

issn = "1590-1874",

publisher = "Springer-Verlag Italia",

number = "4",

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Hye Choi, S, Kim, S, Han, SH, Na, DL, Kim, DK, Cheong, HK, Lee, JH, Kim, SY, Hong, CH, Moon, SY, Kwon, JC, Kim, JE, Jeong, JH, Na, HR, Cha, KR, Seo, SW, Shim, YS, Lee, JY & Park, KW 2012, 'Neurologic signs in relation to cognitive function in subcortical ischemic vascular dementia: A CREDOS (Clinical Research Center for Dementia of South Korea) study', Neurological Sciences, vol. 33, no. 4, pp. 839-846. https://doi.org/10.1007/s10072-011-0845-4

TY - JOUR

T1 - Neurologic signs in relation to cognitive function in subcortical ischemic vascular dementia

T2 - A CREDOS (Clinical Research Center for Dementia of South Korea) study

AU - Hye Choi, Seong

AU - Kim, Sangyun

AU - Han, Seol Heui

AU - Na, Duk L.

AU - Kim, Doh Kwan

AU - Cheong, Hae Kwan

AU - Lee, Jae Hong

AU - Kim, Seong Yoon

AU - Hong, Chang Hyung

AU - Moon, So Young

AU - Kwon, Jay C.

AU - Kim, Jung Eun

AU - Jeong, Jee H.

AU - Na, Hae Ri

AU - Cha, Kyung Ryeol

AU - Seo, Sang Won

AU - Shim, Yong S.

AU - Lee, Jun Young

AU - Park, Kyung Won

N1 - Funding Information: This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A102065).

PY - 2012/8

Y1 - 2012/8

N2 - The objective of this study was to investigate the relationship between neurologic signs and cognitive dysfunction in subcortical ischemic vascular dementia (SIVD). 121 patients with SIVD were recruited from multiple nationwide hospitals. The patients' neurologic signs were evaluated using the Focal Neurologic Sign Score (FNSS). The FNSS scores did not correlate with the composite neuropsychology scores and Korean Mini-Mental State Examination scores. The FNSS scores correlated with the letter fluency and Rey-Osterrieth Complex Figure (ROCF) copy scores.Using a multivariate regression analysis controlled for age, sex, and educational level, the FNSS scores had a significant relationship with the letter fluency test scores (R2 = 0.08, b = -2.28, p = 0.02) and ROCF copy scores (R2 = 0.08, b = -0.42, p = 0.03). These findings suggest that the neurologic signs in patients with SIVD do not correlate with global cognitive functions; however, these signs do correlate with executive dysfunction in these patients.

AB - The objective of this study was to investigate the relationship between neurologic signs and cognitive dysfunction in subcortical ischemic vascular dementia (SIVD). 121 patients with SIVD were recruited from multiple nationwide hospitals. The patients' neurologic signs were evaluated using the Focal Neurologic Sign Score (FNSS). The FNSS scores did not correlate with the composite neuropsychology scores and Korean Mini-Mental State Examination scores. The FNSS scores correlated with the letter fluency and Rey-Osterrieth Complex Figure (ROCF) copy scores.Using a multivariate regression analysis controlled for age, sex, and educational level, the FNSS scores had a significant relationship with the letter fluency test scores (R2 = 0.08, b = -2.28, p = 0.02) and ROCF copy scores (R2 = 0.08, b = -0.42, p = 0.03). These findings suggest that the neurologic signs in patients with SIVD do not correlate with global cognitive functions; however, these signs do correlate with executive dysfunction in these patients.

KW - Cognition

KW - Executive dysfunction

KW - Neurologic sign

KW - Small-vessel disease

KW - Subcortical ischemic vascular dementia

KW - White matter changes

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U2 - 10.1007/s10072-011-0845-4

DO - 10.1007/s10072-011-0845-4

M3 - Article

C2 - 22068220

AN - SCOPUS:84863990143

SN - 1590-1874

VL - 33

SP - 839

EP - 846

JO - Neurological Sciences

JF - Neurological Sciences

IS - 4

ER -

Neurologic signs in relation to cognitive function in subcortical ischemic vascular dementia: A CREDOS (Clinical Research Center for Dementia of South Korea) study

Abstract

Bibliographical note

Keywords

UN SDGs

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