Neuroleptic drugs alter the dopamine transporter-mediated uptake and release of dopamine: A possible mechanism for drug-induced tardive dyskinesia

Sang Hun Lee, Dong Yul Oh, Sung Chul Jung, Young Mi Kim, Hee Kyung Cho, Jai Kyung Koh, Yong Sung Lee

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

A bovine dopamine transporter (bDAT) cDNA was transfected into CV-1 cells, a cell line that lacks vesicular storage and release mechanisms. Using this cell line, the effects of neuroleptic drugs on DAT-mediated uptake and release of dopamine (DA) were examined. All of the neuroleptic drugs tested, inhibited DA uptakes in DAT expressing cells, and most of them were shown to promote spontaneous release of DA at the same time. These results imply that neuroleptic drugs would cause an overflow of DA in the synaptic cleft of extrapyramidal dopaminergic neurons, which could be one of the possible mechanisms of drug-induced tardive dykinesia.

Original languageEnglish
Pages (from-to)447-450
Number of pages4
JournalPharmacological Research
Volume35
Issue number5
DOIs
StatePublished - May 1997

Keywords

  • DAT-mediated uptake and release of dopamine
  • Dopamine transporter (DAT)
  • Neuroleptic drugs
  • Tardive dyskinesia

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