Neuroinflammation in neurodegeneration via microbial infections

Van Thi Ai Tran, Luke P. Lee, Hansang Cho

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Recent epidemiological studies show a noticeable correlation between chronic microbial infections and neurological disorders. However, the underlying mechanisms are still not clear due to the biological complexity of multicellular and multiorgan interactions upon microbial infections. In this review, we show the infection leading to neurodegeneration mediated by multiorgan interconnections and neuroinflammation. Firstly, we highlight three inter-organ communications as possible routes from infection sites to the brain: nose-brain axis, lung-brain axis, and gut-brain axis. Next, we described the biological crosstalk between microglia and astrocytes upon pathogenic infection. Finally, our study indicates how neuroinflammation is a critical player in pathogen-mediated neurodegeneration. Taken together, we envision that antibiotics targeting neuro-pathogens could be a potential therapeutic strategy for neurodegeneration.

Original languageEnglish
Article number907804
JournalFrontiers in Immunology
StatePublished - 28 Jul 2022

Bibliographical note

Funding Information:
This study was supported by the National Research Foundation (grant numbers: NRF-2020R1A2C2010285, NRF 2018M3C7A1056896, and NRF- I21SS7606036) to HC.

Publisher Copyright:
Copyright © 2022 Tran, Lee and Cho.


  • infection
  • multi-organ
  • neurodegeneration
  • neuroinflammation
  • pathogen


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