Neurocognitive changes and their neural correlates in patients with type 2 diabetes mellitus

Junghyun H. Lee, Yera Choi, Chansoo Jun, Young Sun Hong, Han Byul Cho, Jieun E. Kim, In Kyoon Lyoo

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


As the prevalence and life expectancy of type 2 diabetes mellitus (T2DM) continue to increase, the importance of effective detection and intervention for the complications of T2DM, especially neurocognitive complications including cognitive dysfunction and dementia, is receiving greater attention. T2DM is thought to influence cognitive function through an as yet unclear mechanism that involves multiple factors such as hyperglycemia, hypoglycemia, and vascular disease. Recent developments in neuroimaging methods have led to the identification of potential neural correlates of T2DM-related neurocognitive changes, which extend from structural to functional and metabolite alterations in the brain. The evidence indicates various changes in the T2DM brain, including global and regional atrophy, white matter hyperintensity, altered functional connectivity, and changes in neurometabolite levels. Continued neuroimaging research is expected to further elucidate the underpinnings of cognitive decline in T2DM and allow better diagnosis and treatment of the condition.

Original languageEnglish
Pages (from-to)112-121
Number of pages10
JournalEndocrinology and Metabolism
Issue number2
StatePublished - 2014

Bibliographical note

Funding Information:
This work was supported in part by grants A112009 (J.E. Kim) and A121080 (I.K.L.) from the Korean Ministry of Health and Welfare and the Global Top 5 program, Ewha Womans University (I.K.L.).

Publisher Copyright:
© 2014 Korean Endocrine Society.


  • Cognition disorders
  • Dementia
  • Diabetes mellitus
  • Hyperglycemia
  • Hypoglycemia
  • Magnetic resonance imaging
  • Magnetic resonance spectroscopy
  • Type 2


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