Neural network connectivity differences in children who stutter

Soo Eun Chang, David C. Zhu

Research output: Contribution to journalArticlepeer-review

147 Scopus citations

Abstract

Affecting 1% of the general population, stuttering impairs the normally effortless process of speech production, which requires precise coordination of sequential movement occurring among the articulatory, respiratory, and resonance systems, all within millisecond time scales. Those afflicted experience frequent disfluencies during ongoing speech, often leading to negative psychosocial consequences. The aetiology of stuttering remains unclear; compared to other neurodevelopmental disorders, few studies to date have examined the neural bases of childhood stuttering. Here we report, for the first time, results from functional (resting state functional magnetic resonance imaging) and structural connectivity analyses (probabilistic tractography) of multimodal neuroimaging data examining neural networks in children who stutter. We examined how synchronized brain activity occurring among brain areas associated with speech production, and white matter tracts that interconnect them, differ in young children who stutter (aged 3-9 years) compared with age-matched peers. Results showed that children who stutter have attenuated connectivity in neural networks that support timing of self-paced movement control. The results suggest that auditory-motor and basal ganglia-thalamocortical networks develop differently in stuttering children, which may in turn affect speech planning and execution processes needed to achieve fluent speech motor control. These results provide important initial evidence of neurological differences in the early phases of symptom onset in children who stutter.

Original languageEnglish
Pages (from-to)3709-3726
Number of pages18
JournalBrain
Volume136
Issue number12
DOIs
StatePublished - Dec 2013

Bibliographical note

Funding Information:
This study was supported by Award Number #R01DC011277 (PI: Chang) from the National Institute on Deafness and other Communication Disorders (NIDCD). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIDCD or the National Institutes of Health.

Keywords

  • Auditory motor integration
  • Basal ganglia thalamocortical loop
  • DTI probabilistic tractography
  • Resting state functional MRI
  • Stuttering

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