Neu2000 potentiates a kainate response in mouse cortical neurons

Jihyun Noh; Jun Mo Chung

doi:10.1254/jphs.13023SC

Neu2000 potentiates a kainate response in mouse cortical neurons

Jihyun Noh, Jun Mo Chung

Department of Life Science

Research output: Contribution to journal › Article › peer-review

Abstract

Neu2000, acting as an antioxidant with N-methyl-D-aspartate-receptor antagonism, demonstrates excellent protection against ischemic insults in rodents. In this study, we report that Neu2000 also dramatically enhances the activity of kainate (KA) receptors. Neu2000 noncompetitively and reversibly potentiated KA-evoked responses in a voltage-independent manner, mainly by increasing the open probability of KA receptor channels.

Original language	English
Pages (from-to)	149-152
Number of pages	4
Journal	Journal of Pharmacological Sciences
Volume	122
Issue number	2
DOIs	https://doi.org/10.1254/jphs.13023SC
State	Published - 2013

Keywords

Kainic acid
Noise analysis
Voltage-clamp

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10.1254/jphs.13023SC

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title = "Neu2000 potentiates a kainate response in mouse cortical neurons",

abstract = "Neu2000, acting as an antioxidant with N-methyl-D-aspartate-receptor antagonism, demonstrates excellent protection against ischemic insults in rodents. In this study, we report that Neu2000 also dramatically enhances the activity of kainate (KA) receptors. Neu2000 noncompetitively and reversibly potentiated KA-evoked responses in a voltage-independent manner, mainly by increasing the open probability of KA receptor channels.",

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AU - Chung, Jun Mo

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AB - Neu2000, acting as an antioxidant with N-methyl-D-aspartate-receptor antagonism, demonstrates excellent protection against ischemic insults in rodents. In this study, we report that Neu2000 also dramatically enhances the activity of kainate (KA) receptors. Neu2000 noncompetitively and reversibly potentiated KA-evoked responses in a voltage-independent manner, mainly by increasing the open probability of KA receptor channels.

KW - Kainic acid

KW - Noise analysis

KW - Voltage-clamp

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DO - 10.1254/jphs.13023SC

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SP - 149

EP - 152

JO - Journal of Pharmacological Sciences

JF - Journal of Pharmacological Sciences

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ER -

Neu2000 potentiates a kainate response in mouse cortical neurons

Abstract

Keywords

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