Neu2000 potentiates a kainate response in mouse cortical neurons

Jihyun Noh, Jun Mo Chung

Research output: Contribution to journalArticlepeer-review


Neu2000, acting as an antioxidant with N-methyl-D-aspartate-receptor antagonism, demonstrates excellent protection against ischemic insults in rodents. In this study, we report that Neu2000 also dramatically enhances the activity of kainate (KA) receptors. Neu2000 noncompetitively and reversibly potentiated KA-evoked responses in a voltage-independent manner, mainly by increasing the open probability of KA receptor channels.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalJournal of Pharmacological Sciences
Issue number2
StatePublished - 2013


  • Kainic acid
  • Noise analysis
  • Voltage-clamp


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