Abstract
Two new cyanine-based fluorescent probes 1 and 2 have been developed. Probe 1 bears two cyanine units in a single molecule, and probe 2 contains a bis(trifluoromethyl)benzenethiol moiety. Both are non-fluorescent. The addition of intracellular glutathione (GSH) significantly enhanced the NIR fluorescence of the two probes. Both probes were used to image varying amounts of GSH in living cells. In tumor bearing mice, the in vivo fluorescence intensity of both probes was higher in tumors, where GSH is overexpressed, than in normal tissues. These results suggest that these new fluorogenic probes have potential for GSH-targeting diagnostic imaging.
Original language | English |
---|---|
Pages (from-to) | 2541-2546 |
Number of pages | 6 |
Journal | Journal of Materials Chemistry B |
Volume | 6 |
Issue number | 17 |
DOIs | |
State | Published - 2018 |
Bibliographical note
Publisher Copyright:© 2018 The Royal Society of Chemistry.