Nanovesicle-based bioelectronic nose platform mimicking human olfactory signal transduction

Hye Jun Jin, Sang Hun Lee, Tae Hyun Kim, Juhun Park, Hyun Seok Song, Tai Hyun Park, Seunghun Hong

Research output: Contribution to journalArticlepeer-review

127 Scopus citations


We developed a nanovesicle-based bioelectronic nose (NBN) that could recognize a specific odorant and mimic the receptor-mediated signal transmission of human olfactory systems. To build an NBN, we combined a single-walled carbon nanotube-based field effect transistor with cell-derived nanovesicles containing human olfactory receptors and calcium ion signal pathways. Importantly, the NBN took advantages of cell signal pathways for sensing signal amplification, enabling ∼100 times better sensitivity than that of previous bioelectronic noses based on only olfactory receptor protein and carbon nanotube transistors. The NBN sensors exhibited a human-like selectivity with single-carbon-atomic resolution and a high sensitivity of 1. fM detection limit. Moreover, this sensor platform could mimic a receptor-meditated cellular signal transmission in live cells. This sensor platform can be utilized for the study of molecular recognition and biological processes occurring at cell membranes and also for various practical applications such as food screening and medical diagnostics.

Original languageEnglish
Pages (from-to)335-341
Number of pages7
JournalBiosensors and Bioelectronics
Issue number1
StatePublished - 15 May 2012

Bibliographical note

Funding Information:
This work was supported by the NRF grant (No. 2011-0000390 , 2011-0000331 , 2010-0005574 , 2011-0020984 ) and the Conversing Research Center Program (No. 2011K000683 , No. 2011K000682 ). SH acknowledges the support from the WCU program ( R31-10032 ) and the NBIT program (No. 2011-00240 ). Following are results of a study on the “Human Resource Development Center for Economic Region Leading Industry” Project, supported by the Ministry of Education, Science & Technology (MEST) and the National Research Foundation of Korea (NRF) .


  • Bioelectronic nose
  • Carbon nanotube
  • Field effect transistor
  • Human olfactory receptor
  • Nanobiosensor
  • Nanovesicle


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