@inproceedings{cd07abcf61a9492dba0f26253de58d13,
title = "Nanoscopic monitroing of cytochrome c nitrosylation by plasmonic energy tranfer (PRET)",
abstract = "Label-free and real-time spectroscopic monitoring method for living cells is missing since current cellular imaging is based on fluorescent labeling, which cannot provide us fingerprints of molecules. We utilized Plasmon Resonance Energy Transfer (PRET)-based single-cell-level spectroscopy via nanoplasmonic probes (NPs) to differentiate the states of Cytochrome c (Cyt c) and monitor in-situ intracellular nitrosylation. The states were differentiated through quantized-dips within Rayleigh scattering spectrum of the NPs. Furthermore, endogenously nitrosylated Cyt c under apoptosis were measured by PRET. We expect this PRET-based detection has the potential to provide a novel platform to the fields of systems biology.",
keywords = "Label-free, Nanoplasmonic probes, Nitrosylation, Plasmon Resonance Energy Transfer (PRET), Systems biology",
author = "Lee, {Sung S.} and Lo, {Joe F.} and San Pun and Lee, {Luke P.}",
year = "2009",
language = "English",
isbn = "9780979806421",
series = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "302--304",
booktitle = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
note = "13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 ; Conference date: 01-11-2009 Through 05-11-2009",
}