Nanoplasmonic gene regulation

Somin Eunice Lee, Luke P. Lee

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


This review focuses on the recent developments in nanoplasmonic gene regulations. Types of nanoplasmonic carriers and DNA/RNA cargo are described. Strategies to liberate cargo from their carriers using NIR and enable on-demand silencing of endogenous intracellular genes are reviewed. In addition to inhibitory effects, exogenous foreign genes are also introduced and expressed on-demand using nanoplasmonic optical switches. The magnitude and timing of genetic activities can therefore be systematically controlled on-demand remotely. Equipped with new nanoplasmonic optics to directly probe the intracellular space, quantitative approaches should capture many dynamic activities within living systems that were otherwise previously impossible to control using conventional methods.

Original languageEnglish
Pages (from-to)623-633
Number of pages11
JournalCurrent Opinion in Chemical Biology
Issue number5
StatePublished - Oct 2010

Bibliographical note

Funding Information:
The authors acknowledge the Siebel Foundation and the National Institutes of Health (NIH) Nanomedicine Development Center for the Optical Control of Biological Function (PN2 EY018241) for financial support. The authors thank Prof. Han Lim and Prof. Robert Fischer for insightful discussion on systems biology.


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