we report the design, fabrication, characterizations of a biocompatible single composite nanocrescent SERS nanoprobe, which can function not only as standalone SERS substrates, but also has a magnetically controllable capability in orientation and translation motions. The circular orifice of sharp-edged single nanocrescent allows multiple coupling of integrated SERS hot spots. The nanocrescent as a single SERS nanoprobe demonstrates more than 108 times higher local field enhancement factor than single metallic nanospheres especially in the near infrared range because of the hybrid plasmon resonance modes. Since our nanoscrescent is formed by Au/Ag/Fe/Au composite layers, we can modulate not only its orientation to find maximized local field enhancement and SERS enhancement factors with respect to the excitation source, but also the translational positions and motions by external magnetic fields. Magnetically modulated SERS detection of molecules on a single composite nanocrescent probe is demonstrated.