Nanoparticulate platinum(II) anticancer drug: Synthesis and characterization of amphiphilic cyclotriphosphazene-platinum(II) conjugates

Ji Young Yu; Yong Joo Jun; Soo Hyun Jang; Hwa Jeong Lee; Youn Soo Sohn

doi:10.1016/j.jinorgbio.2007.07.003

Nanoparticulate platinum(II) anticancer drug: Synthesis and characterization of amphiphilic cyclotriphosphazene-platinum(II) conjugates

Ji Young Yu, Yong Joo Jun, Soo Hyun Jang, Hwa Jeong Lee, Youn Soo Sohn

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Novel cyclotriphosphazene-platinum(II) conjugates were prepared by hydrolysis and platination of the amphiphilic cyclotriphosphazenes grafted with equimolar hydrophilic methoxy-poly(ethylene glycol) (MPEG) and hydrophobic oligopeptide. These macromolecular conjugates were found to form stable nanoparticles with a mean diameter of approximately 90-200 nm depending on the hydrophobicity of the conjugated (diamine)platinum moieties. The nanoparticulate platinum(II) conjugates have shown temperature and concentration dependent particle sizes. However, the particle sizes of the conjugates were found to decrease to a certain size as the solution concentration was decreased but remained stable even at 10 μM, which is enough for systemic delivery by injection. The conjugates exhibited lower in vitro cytotoxicity than cisplatin but reasonably good activity against selected human tumor cell lines.

Original language	English
Pages (from-to)	1931-1936
Number of pages	6
Journal	Journal of Inorganic Biochemistry
Volume	101
Issue number	11-12
DOIs	https://doi.org/10.1016/j.jinorgbio.2007.07.003
State	Published - Nov 2007

Bibliographical note

Funding Information:
This work was supported by the SRC program of the Korea Science and Engineering Foundation through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (Grant R11-2005-008-01002-0), by a Korean Research Foundation Grant (KRF-2004-005-C00090), and Ministry of Commerce, Industry and Energy of Korea.

Keywords

Antitumor agent
Cyclotriphosphazene
Platinum conjugate
Tumor selectivity

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title = "Nanoparticulate platinum(II) anticancer drug: Synthesis and characterization of amphiphilic cyclotriphosphazene-platinum(II) conjugates",

abstract = "Novel cyclotriphosphazene-platinum(II) conjugates were prepared by hydrolysis and platination of the amphiphilic cyclotriphosphazenes grafted with equimolar hydrophilic methoxy-poly(ethylene glycol) (MPEG) and hydrophobic oligopeptide. These macromolecular conjugates were found to form stable nanoparticles with a mean diameter of approximately 90-200 nm depending on the hydrophobicity of the conjugated (diamine)platinum moieties. The nanoparticulate platinum(II) conjugates have shown temperature and concentration dependent particle sizes. However, the particle sizes of the conjugates were found to decrease to a certain size as the solution concentration was decreased but remained stable even at 10 μM, which is enough for systemic delivery by injection. The conjugates exhibited lower in vitro cytotoxicity than cisplatin but reasonably good activity against selected human tumor cell lines.",

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author = "Yu, {Ji Young} and Jun, {Yong Joo} and Jang, {Soo Hyun} and Lee, {Hwa Jeong} and Sohn, {Youn Soo}",

note = "Funding Information: This work was supported by the SRC program of the Korea Science and Engineering Foundation through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (Grant R11-2005-008-01002-0), by a Korean Research Foundation Grant (KRF-2004-005-C00090), and Ministry of Commerce, Industry and Energy of Korea.",

year = "2007",

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doi = "10.1016/j.jinorgbio.2007.07.003",

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AU - Jang, Soo Hyun

AU - Lee, Hwa Jeong

AU - Sohn, Youn Soo

N1 - Funding Information: This work was supported by the SRC program of the Korea Science and Engineering Foundation through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (Grant R11-2005-008-01002-0), by a Korean Research Foundation Grant (KRF-2004-005-C00090), and Ministry of Commerce, Industry and Energy of Korea.

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AB - Novel cyclotriphosphazene-platinum(II) conjugates were prepared by hydrolysis and platination of the amphiphilic cyclotriphosphazenes grafted with equimolar hydrophilic methoxy-poly(ethylene glycol) (MPEG) and hydrophobic oligopeptide. These macromolecular conjugates were found to form stable nanoparticles with a mean diameter of approximately 90-200 nm depending on the hydrophobicity of the conjugated (diamine)platinum moieties. The nanoparticulate platinum(II) conjugates have shown temperature and concentration dependent particle sizes. However, the particle sizes of the conjugates were found to decrease to a certain size as the solution concentration was decreased but remained stable even at 10 μM, which is enough for systemic delivery by injection. The conjugates exhibited lower in vitro cytotoxicity than cisplatin but reasonably good activity against selected human tumor cell lines.

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KW - Tumor selectivity

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Nanoparticulate platinum(II) anticancer drug: Synthesis and characterization of amphiphilic cyclotriphosphazene-platinum(II) conjugates

Abstract

Bibliographical note

Keywords

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