Nanoparticle-based combination therapy for cancer treatment

Ji Young Yhee, Sejin Son, Hyukjin Lee, Kwangmeyung Kim

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


In recent years, combination of different types of therapies using nanoparticles has emerged as an advanced strategy for cancer treatment. Most of all, combination of chemotherapeutic drug and siRNA in nanoformulation has shown a great potential, because siRNA-mediated specific gene silencing can compensate for the incomplete anti-cancer actions of chemotherapy. In this article, nanoparticle-based combination therapy for cancer treatment is introduced to be focused on the therapeutic chemical and siRNA combination. It is classified into 3 groups: 1) general chemotherapy combined with siRNA carrying nanoparticle, 2) co-delivery of chemical and siRNA therapeutics within a single nanoparticle, and 3) Use of multiple nanoparticles for chemical and siRNA therapeutics. The purpose of the combination and the mechanisms of anti-cancer action was described according to the categories. Examples of some recent developments of nanotechnology-based chemo- and siRNA- therapeutics combination therapy are summarized for better understanding of its practical application.

Original languageEnglish
Pages (from-to)3158-3166
Number of pages9
JournalCurrent Pharmaceutical Design
Issue number22
StatePublished - 1 Jul 2015

Bibliographical note

Publisher Copyright:
© 2015 Bentham Science Publishers.


  • Cancer
  • Combination therapy
  • Nanoparticle
  • Targeted drug delivery


Dive into the research topics of 'Nanoparticle-based combination therapy for cancer treatment'. Together they form a unique fingerprint.

Cite this