Nanodrug delivery system for precision treatment of pulmonary fibrosis

Xiner Yi; Xinru Zhang; Yuanye Guan; Yizhe Sha; Xiaoliang Cheng; Yonghyun Lee; Wei En Yuan

doi:10.1016/j.preme.2025.100025

Nanodrug delivery system for precision treatment of pulmonary fibrosis

Xiner Yi
, Xinru Zhang
, Yuanye Guan
, Yizhe Sha
, Xiaoliang Cheng
, Yonghyun Lee
, Wei En Yuan

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Pulmonary fibrosis (PF) is a chronic lung disease with high morbidity and mortality, complex pathological mechanisms and limited available treatments. Recently, the rapid development of nanotechnology has brought new hope for treating PF. Owing to their unique advantages in drug delivery, oxidative stress modulation, and gene protection, nanomaterials are capable of optimizing therapeutic efficacy and reversing side effects. In this review, the basic pathological mechanisms of PF are first introduced. Second, the application potential of various nanomaterials for treating PF is summarized. Finally, their advantages and challenges are discussed in detail, providing references for developing more promising and precise therapeutic strategies in the future.

Original language	English
Article number	100025
Journal	Precision Medicine and Engineering
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/j.preme.2025.100025
State	Published - Jun 2025

Bibliographical note

Publisher Copyright:
© 2025 The Authors. Published by Elsevier B.V. on behalf of Zhejiang University and Zhejiang University Press. This is an open access article under the CC BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords

Idiopathic pulmonary fibrosis
Nanomaterials
Pulmonary fibrosis
Targeted drug delivery

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10.1016/j.preme.2025.100025

Cite this

@article{0322d1f2006144f9ab50bc295fb1837c,

title = "Nanodrug delivery system for precision treatment of pulmonary fibrosis",

abstract = "Pulmonary fibrosis (PF) is a chronic lung disease with high morbidity and mortality, complex pathological mechanisms and limited available treatments. Recently, the rapid development of nanotechnology has brought new hope for treating PF. Owing to their unique advantages in drug delivery, oxidative stress modulation, and gene protection, nanomaterials are capable of optimizing therapeutic efficacy and reversing side effects. In this review, the basic pathological mechanisms of PF are first introduced. Second, the application potential of various nanomaterials for treating PF is summarized. Finally, their advantages and challenges are discussed in detail, providing references for developing more promising and precise therapeutic strategies in the future.",

keywords = "Idiopathic pulmonary fibrosis, Nanomaterials, Pulmonary fibrosis, Targeted drug delivery",

author = "Xiner Yi and Xinru Zhang and Yuanye Guan and Yizhe Sha and Xiaoliang Cheng and Yonghyun Lee and Yuan, \{Wei En\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors. Published by Elsevier B.V. on behalf of Zhejiang University and Zhejiang University Press. This is an open access article under the CC BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0/",

year = "2025",

month = jun,

doi = "10.1016/j.preme.2025.100025",

language = "English",

volume = "2",

journal = "Precision Medicine and Engineering",

issn = "2950-4821",

publisher = "Elsevier BV",

number = "2",

}

TY - JOUR

T1 - Nanodrug delivery system for precision treatment of pulmonary fibrosis

AU - Yi, Xiner

AU - Zhang, Xinru

AU - Guan, Yuanye

AU - Sha, Yizhe

AU - Cheng, Xiaoliang

AU - Lee, Yonghyun

AU - Yuan, Wei En

N1 - Publisher Copyright: © 2025 The Authors. Published by Elsevier B.V. on behalf of Zhejiang University and Zhejiang University Press. This is an open access article under the CC BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0/

PY - 2025/6

Y1 - 2025/6

N2 - Pulmonary fibrosis (PF) is a chronic lung disease with high morbidity and mortality, complex pathological mechanisms and limited available treatments. Recently, the rapid development of nanotechnology has brought new hope for treating PF. Owing to their unique advantages in drug delivery, oxidative stress modulation, and gene protection, nanomaterials are capable of optimizing therapeutic efficacy and reversing side effects. In this review, the basic pathological mechanisms of PF are first introduced. Second, the application potential of various nanomaterials for treating PF is summarized. Finally, their advantages and challenges are discussed in detail, providing references for developing more promising and precise therapeutic strategies in the future.

AB - Pulmonary fibrosis (PF) is a chronic lung disease with high morbidity and mortality, complex pathological mechanisms and limited available treatments. Recently, the rapid development of nanotechnology has brought new hope for treating PF. Owing to their unique advantages in drug delivery, oxidative stress modulation, and gene protection, nanomaterials are capable of optimizing therapeutic efficacy and reversing side effects. In this review, the basic pathological mechanisms of PF are first introduced. Second, the application potential of various nanomaterials for treating PF is summarized. Finally, their advantages and challenges are discussed in detail, providing references for developing more promising and precise therapeutic strategies in the future.

KW - Idiopathic pulmonary fibrosis

KW - Nanomaterials

KW - Pulmonary fibrosis

KW - Targeted drug delivery

UR - https://www.scopus.com/pages/publications/105024830775

U2 - 10.1016/j.preme.2025.100025

DO - 10.1016/j.preme.2025.100025

M3 - Review article

AN - SCOPUS:105024830775

SN - 2950-4821

VL - 2

JO - Precision Medicine and Engineering

JF - Precision Medicine and Engineering

IS - 2

M1 - 100025

ER -

Nanodrug delivery system for precision treatment of pulmonary fibrosis

Abstract

Bibliographical note

Keywords

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