TY - JOUR
T1 - Nano theranostics platforms that utilize proteins
AU - Lee, Songyi
AU - Pham, Thanh Chung
AU - Bae, Chaeeon
AU - Choi, Yeonghwan
AU - Kim, Yong Kyun
AU - Yoon, Juyoung
N1 - Publisher Copyright:
© 2020
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Proteins have received increasing attention as a novel platform for drug delivery and phototheranostic agents that may serve as new nanomedicines. In drug delivery system, proteins can act as powerful tools with self-assembled structures, triggering groups, receptors and agents to enhance cell penetration. Compared to other nanoparticle based theranostics, nano-platforms for theranostics by utilizing proteins have unique merits, such as higher loading capacities and high efficiency of photosensitizers in phototherapies. However, the full potential of protein-based theranostics has not been achieved thus far. In this review, recent advances made in this area were discussed following a format based on proteins in drug delivery systems, proteins-dye complexes for phototherapy of cancer, proteins nanoparticles for imaging-guided cancer therapy such as fluorescent imaging, positron emission tomography (PET), magnetic resonance imaging (MRI), ultrasound (US) Imaging, PA imaging and proteins-based nanoprobes and nanostructures. Importantly, this discussion also provides a view of future advances that will likely be made in this area and their potential clinical applications.
AB - Proteins have received increasing attention as a novel platform for drug delivery and phototheranostic agents that may serve as new nanomedicines. In drug delivery system, proteins can act as powerful tools with self-assembled structures, triggering groups, receptors and agents to enhance cell penetration. Compared to other nanoparticle based theranostics, nano-platforms for theranostics by utilizing proteins have unique merits, such as higher loading capacities and high efficiency of photosensitizers in phototherapies. However, the full potential of protein-based theranostics has not been achieved thus far. In this review, recent advances made in this area were discussed following a format based on proteins in drug delivery systems, proteins-dye complexes for phototherapy of cancer, proteins nanoparticles for imaging-guided cancer therapy such as fluorescent imaging, positron emission tomography (PET), magnetic resonance imaging (MRI), ultrasound (US) Imaging, PA imaging and proteins-based nanoprobes and nanostructures. Importantly, this discussion also provides a view of future advances that will likely be made in this area and their potential clinical applications.
KW - Bioimaging
KW - Drug delivery
KW - Imaging-guided cancer therapy
KW - Phototherapy
KW - Protein-based theranostics
UR - http://www.scopus.com/inward/record.url?scp=85080072054&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2020.213258
DO - 10.1016/j.ccr.2020.213258
M3 - Review article
AN - SCOPUS:85080072054
SN - 0010-8545
VL - 412
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
M1 - 213258
ER -