Nano-enabled delivery systems across the blood-brain barrier

Seung Rim Hwang, Kwangmeyung Kim

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations


The development of drugs to treat disorders of the central nervous system (CNS) faces difficulties in achieving penetration of a drug through the blood-brain barrier (BBB) and allowing the drug to reach its intended target in the brain. There have been strategies to improve drug delivery to the brain through endogenous transport pathways such as passive diffusion, endocytosis, and active transport. Among various strategies, nano-enabled delivery systems offer a promising solution to improve the uptake and targeted delivery of drugs into the brain. Various nanocarriers including liposomes, bolaamphiphiles and nanoparticles can be used as a means to encapsulate drugs, either alone or in combination with targeting ligands. Moreover, most of materials used in nanocarrier fabrication are both biodegradable and biocompatible, thereby increasing the clinical utility of them. Here, we review the possibility to employ nano-enabled materials for delivery of drug across the BBB and the recent advances in nanotechnologies for therapy of the CNS diseases.

Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalArchives of Pharmacal Research
Issue number1
StatePublished - Jan 2014

Bibliographical note

Funding Information:
Acknowledgments This work was supported by the Intramural Research Program (Theragnosis, Global RNAi Carrier Initiative, and KIST Young Fellow) of KIST.


  • Blood-brain barrier
  • Central nervous system
  • Nano-enabled delivery
  • Nanotechnology
  • Receptor-mediated transcytosis


Dive into the research topics of 'Nano-enabled delivery systems across the blood-brain barrier'. Together they form a unique fingerprint.

Cite this