β-amino alcohols are selectively N-thioacylated by N- (thioacyl)phthalimides under very mild conditions to provide N- (hydroxyethyl)thioamides in high yields. Cyclodehydration with Burgess reagent then provides α-amino acid thiazolines. This approach provides a convenient alternative to those based upon thionation of a preformed N- (hydroxyethyl)amide.
|Number of pages||4|
|State||Published - 1 Jan 1998|