TY - JOUR
T1 - N-methyl-D-aspartate receptor antagonists enhance the head-twitch response, a 5-hydroxytryptamine2 receptor-mediated behaviour, in reserpine-treated mice
AU - Kim, Hack Seang
AU - Park, In Sook
AU - Lim, Hwa Kyung
AU - Choi, Hong Serck
AU - Oh, Seikwan
AU - Park, Woo Kyu
AU - Jang, Choon Gon
AU - Kim, Seung Hwan
AU - Chang, Myung Jei
PY - 2000/6
Y1 - 2000/6
N2 - In this study, N-methyl-D-aspartate (NMDA)-receptor antagonists enhanced the head-twitch response induced by 5-hydroxytryptamine (5-HT) in reserpine-treated mice. To minimize the risk of any indirect involvement of NMDA-receptor antagonists (D(-)-2-amino-5-phosphonopentanoic acid (AP-5), D(-)-3(2-carboxypiperazine-4-yl)-propyl-l-phosphonic acid (CPP), (+)-5-methyl-10,11-dihydroxy-5H-dibenzo-[a,d]-cyclohepten-5,10-imine (MK-801), ketamine, dextrorphan and dextromethorpan) with 5-HT neurones, vesicle stores of monoamines, especially 5-HT, were depleted with reserpine. In addition, the enhancement of 5-HT-induced head-twitch response was inhibited by apomorphine and NMDA as well as ritanserin in reserpine-treated mice. These results support our previous conclusion that NMDA receptors play important roles in the glutamatergic modulation of 5-HTergic function at the postsynaptic 5-HT2 receptors in mice.
AB - In this study, N-methyl-D-aspartate (NMDA)-receptor antagonists enhanced the head-twitch response induced by 5-hydroxytryptamine (5-HT) in reserpine-treated mice. To minimize the risk of any indirect involvement of NMDA-receptor antagonists (D(-)-2-amino-5-phosphonopentanoic acid (AP-5), D(-)-3(2-carboxypiperazine-4-yl)-propyl-l-phosphonic acid (CPP), (+)-5-methyl-10,11-dihydroxy-5H-dibenzo-[a,d]-cyclohepten-5,10-imine (MK-801), ketamine, dextrorphan and dextromethorpan) with 5-HT neurones, vesicle stores of monoamines, especially 5-HT, were depleted with reserpine. In addition, the enhancement of 5-HT-induced head-twitch response was inhibited by apomorphine and NMDA as well as ritanserin in reserpine-treated mice. These results support our previous conclusion that NMDA receptors play important roles in the glutamatergic modulation of 5-HTergic function at the postsynaptic 5-HT2 receptors in mice.
UR - http://www.scopus.com/inward/record.url?scp=0034089126&partnerID=8YFLogxK
U2 - 10.1211/0022357001774390
DO - 10.1211/0022357001774390
M3 - Article
C2 - 10875549
AN - SCOPUS:0034089126
SN - 0022-3573
VL - 52
SP - 717
EP - 722
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
IS - 6
ER -