N-α-acetyltransferase 10 (NAA10) in development: the role of NAA10

Mi Ni Lee; Hyae Yon Kweon; Goo Taeg Oh

doi:10.1038/s12276-018-0105-2

N-α-acetyltransferase 10 (NAA10) in development: the role of NAA10

Mi Ni Lee, Hyae Yon Kweon, Goo Taeg Oh

Department of Life Science

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

N-α-acetyltransferase 10 (NAA10) is a subunit of N^α-terminal protein acetyltransferase that plays a role in many biological processes. Among the six N-α-acetyltransferases (NATs) in eukaryotes, the biological significance of the N-terminal acetyl-activity of Naa10 has been the most studied. Recent findings in a few species, including humans, indicate that loss of N-terminal acetylation by NAA10 is associated with developmental defects. However, very little is known about the role of NAA10, and more research is required in relation to the developmental process. This review summarizes recent studies to understand the function of NAA10 in the development of multicellular organisms.

Original language	English
Article number	87
Journal	Experimental and Molecular Medicine
Volume	50
Issue number	7
DOIs	https://doi.org/10.1038/s12276-018-0105-2
State	Published - 1 Jul 2018

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abstract = "N-α-acetyltransferase 10 (NAA10) is a subunit of Nα-terminal protein acetyltransferase that plays a role in many biological processes. Among the six N-α-acetyltransferases (NATs) in eukaryotes, the biological significance of the N-terminal acetyl-activity of Naa10 has been the most studied. Recent findings in a few species, including humans, indicate that loss of N-terminal acetylation by NAA10 is associated with developmental defects. However, very little is known about the role of NAA10, and more research is required in relation to the developmental process. This review summarizes recent studies to understand the function of NAA10 in the development of multicellular organisms.",

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AB - N-α-acetyltransferase 10 (NAA10) is a subunit of Nα-terminal protein acetyltransferase that plays a role in many biological processes. Among the six N-α-acetyltransferases (NATs) in eukaryotes, the biological significance of the N-terminal acetyl-activity of Naa10 has been the most studied. Recent findings in a few species, including humans, indicate that loss of N-terminal acetylation by NAA10 is associated with developmental defects. However, very little is known about the role of NAA10, and more research is required in relation to the developmental process. This review summarizes recent studies to understand the function of NAA10 in the development of multicellular organisms.

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N-α-acetyltransferase 10 (NAA10) in development: the role of NAA10

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